ADAMTS8
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Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 8 -
Overview
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008] -
Synonyms
ADAMTS8;ADAM metallopeptidase with thrombospondin type 1 motif, 8;METH2;ADAM-TS8;A disintegrin and metalloproteinase with thrombospondin motifs 8;METH-2;METH-8;ADAMTS-8;ADAM-TS 8;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
Recombinant Proteins
- Human
- Mouse
- E.coli
- E.Coli/Yeast
- Wheat Germ
- HEK293
- Mammalian Cells
- His
- GST
- Non
- His&SUMO
- DDK&Myc
- Avi&Fc&His
- Flag
Involved Pathway
ADAMTS8 involved in several pathways and played different roles in them. We selected most pathways ADAMTS8 participated on our site, such as Degradation of the extracellular matrix,Extracellular matrix organization,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | LMAN2L,PREB,MUC1,EIF2B1,GPR120,SLC25A12,SLC30A8,DPH5,MPDU1,MAN1A2 |
| O-glycosylation of TSR domain-containing proteins | THSD7A,ADAMTS10,ADAMTS13,C8orf84,ADAMTSL4,ADAMTSL5,SSPO,ADAMTS20,SPON1A,ADAMTS18 |
| O-linked glycosylation | A4GNT,MUC20,B3GNT2A,KCNA6,ADAMTS20,GALNT13,C8orf84,ADAMTSL1,ADAMTSL5,GALNT6 |
| Extracellular matrix organization | LOXL1,COL4A5,COL28A1D,KLK7,ITGB3A,FURINA,FAM49BA,ADAMTS4,VCANB,TLL1 |
| Post-translational protein modification | TRAPPC4,SLC35A1,ADAMTS1,NAPAA,CNIH2,SPON1A,PROZ,PHC3,ZNF408,MLEC |
| Degradation of the extracellular matrix | CMA1,FAM49BA,TLDC2,MMP13,COL23A1,MGC174857,COL13A1,CTSLL,COL25A1,MGC174155 |
Protein Function
ADAMTS8 has several biochemical functions, for example, heparin binding,integrin binding,low-affinity phosphate transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS8 itself. We selected most functions ADAMTS8 had, and list some proteins which have the same functions with ADAMTS8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | WISP1A,FAP,NF2,ECM2,ITGB1,FN1A,NISCH,CALR,FN1,FBLN1 |
| zinc ion binding | CPM,UNK,RNF150,HIF1AN,WBP2NL,ADAM5P,WT1,MSRB3,EEA1,NR5A1 |
| metalloendopeptidase activity | MMP26,MEP1A,GM12824,ADAMDEC1,PAPPA,BMP1A,AFG3L2,ADAMTS18,YME1L1,HE2 |
| metallopeptidase activity | MMP14B,CLCA3,CLCA5,ANPEPB,Npepo,AMZ2,ENPEP,CLCA4,LNPEP,NAALAD2 |
| heparin binding | CTSG,VTN,CYR61,TGFBR3,APPB,PCSK6,FGFRL1,RSPO2,PRELP,VEGFB |
Interacting Protein
ADAMTS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS8.
Resources
Research Area
Angiogenesis InhibitorMetalloproteases and Regulators
Angiogenesis Inhibitor in Cancer
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References
