ADAMTS12
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Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 12 -
Overview
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008] -
Synonyms
ADAMTS12;ADAM metallopeptidase with thrombospondin type 1 motif, 12;PRO4389;A disintegrin and metalloproteinase with thrombospondin motifs 12;ADAM-TS12;ADAMTS-12;ADAM-TS 12;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ADAMTS12-298H | Recombinant Human ADAMTS12 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ADAMTS12-3006M | Recombinant Mouse ADAMTS12, His-tagged | E.coli | Mouse | His | 34350 |
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| ADAMTS12-1485H | Recombinant Human ADAMTS12 protein, His-tagged | E.coli | Human | His | Gln823~Pro997 |
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| ADAMTS12-916HF | Recombinant Full Length Human ADAMTS12 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 229 amino acids |
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Involved Pathway
ADAMTS12 involved in several pathways and played different roles in them. We selected most pathways ADAMTS12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ADAMTS12 has several biochemical functions, for example, hydrolase activity,metal ion binding,metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS12 itself. We selected most functions ADAMTS12 had, and list some proteins which have the same functions with ADAMTS12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metallopeptidase activity | Npepo,ADAMTSL1,C6AST4,ADAM5,ERAP2,BMP1A,C6AST1,ADAM1B,ADAM10A,XPNPEP3 |
| hydrolase activity | NUDT4A,EAR3,G6PC3,FBP1B,ATP8B3,DNASE1L3L,HTRA1B,CLCA3,DHX37,GCH2 |
| metal ion binding | ROCK2,ZNF771,ITGAM,AGFG1B,ZFP39,NMRK2,KLK1B4,NDUFS1,HNRNPA0L,JADE1 |
| peptidase activity | F2RL1.1,OTUD7A,ADAMTS7,GZMF,HTRA2,CTSH,TMPRSS11F,BMP1,KLK7,KLK1B11 |
| zinc ion binding | CA15A,RFPL4B,MORC1,DDX41,WBP7,CAHZ,TRIM55A,RNF34,LHX1B,CA15C |
| metalloendopeptidase activity | ADAM10B,MMP14B,HE2,ADAMTS20,ADAM10A,UQCRC2A,ADAM10,ADAM22,MMP10,MMP13A |
Interacting Protein
ADAMTS12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS12.
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