ADAM10
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Official Full Name
ADAM metallopeptidase domain 10 -
Overview
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008] -
Synonyms
ADAM10;ADAM metallopeptidase domain 10;RAK;kuz;AD10;AD18;MADM;CD156c;HsT18717;disintegrin and metalloproteinase domain-containing protein 10;CDw156;kuzbanian protein homolog;mammalian disintegrin-metalloprotease;a disintegrin and metalloprotease domain 10
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Sf21 Cells
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- CHO
- His
- GST
- Avi
- Fc
Involved Pathway
ADAM10 involved in several pathways and played different roles in them. We selected most pathways ADAM10 participated on our site, such as Activated NOTCH1 Transmits Signal to the Nucleus,Alzheimers disease,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | HDAC6,HEYL,CDK8,JAG2,JAG1,HDAC5,HEY2,HEY1,MIB1,CCNC |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | JAG1,MIB1,JAG2 |
| Collagen degradation | MMP12,COL13A1,ADAM9,MMP15,MGC174857,COL9A1,EMID2,MMP20,MMP11,COL17A1 |
| Alzheimers disease | PPP3CA,ATP2A3,CALM3,BID,GRIN2B,NDUFA9,APBB1,COX7A2L,PPP3R2,HSD17B10 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | HDAC6,HEY2,CCNC,MIB1,CDK8,JAG1,JAG2,HDAC5,HEYL,HEY1 |
| Axon guidance | DUSP9,EPHA8,GNAI2,EFNA1,CDK5,DUSP4,RHOGA,PPP3CA,DPYSL5B,AGRN |
| Activated NOTCH1 Transmits Signal to the Nucleus | JAG1,DNER,CNTN1,MIB1,JAG2,DLK1,DTX2 |
Protein Function
ADAM10 has several biochemical functions, for example, SH3 domain binding,endopeptidase activity,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM10 itself. We selected most functions ADAM10 had, and list some proteins which have the same functions with ADAM10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloendopeptidase activity | MMP8,AFG3L2,HE1A,OMA1,MMP9,MMP20,OSGEPL1,ADAMTS9,MMP24,MIPEP |
| zinc ion binding | MMP23B,MARCH5L,MICALL1,CA5A,RNPEPL1,RNF166,RCHY1,ZFAND6,IDE,TRIM24 |
| integrin binding | CYR61L1,CD9,ITGB1BP1,ECM2,FN1A,NISCH,ADAM17,ITGA5,FAP,AMICA1 |
| SH3 domain binding | INPPL1,PLSCR3,OSTF1,ADAM17,ITM2B,MYPN,MAPT,GPX1,PLSCR1,SH3BGRL2 |
| metallopeptidase activity | ERMP1,ADAM20,Adamts19,TAF2,DPEP3,BMP1B,C6AST3,ADAMTS16,ANPEPB,ADAM25 |
| protein kinase binding | CAV1,CD24,ACSL3,PTPRK,PPP1R12B,CCNB1,DOK7,HNRNPA0,TRAP1,PTPN23 |
| endopeptidase activity | PSMA4,KLK1B8,PSMA5,MMP9,PSMB8F,APH1B,TMEM59,PSEN2,FURIN,KLK1B5 |
| protein homodimerization activity | PML,BMP2B,HHEX,MAP3K9,PVR,CECR1,LRP4,PDCD10,TERF1,SUPV3L1 |
| receptor binding | CROT,CAT,PTK2AB,LRP6,INSL3,SRI,PVRL1A,GNPAT,EHHADH,PVRL1B |
Interacting Protein
ADAM10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM10.
PDIA3;AR;PHB;btuB;pi3p;CD9
Resources
Research Area
ADAMs on Endothelial CellsNotch Family
Alzheimer's Disease
Metalloproteases and Regulators
E-Cadherin Ectodomain Shedding and Proteolytic Processing
Related Services
Related Products
References
- Martin, RK; Brooks, KB; et al. Antigen Transfer from Exosomes to Dendritic Cells as an Explanation for the Immune Enhancement Seen by IgE Immune Complexes. PLOS ONE 9:-(2014).
- Sampedro, GR; DeDent, AC; et al. Targeting Staphylococcus aureus alpha-Toxin as a Novel Approach to Reduce Severity of Recurrent Skin and Soft-Tissue Infections. JOURNAL OF INFECTIOUS DISEASES 210:1012-1018(2014).
