ADAM10

  • Official Full Name

    ADAM metallopeptidase domain 10

  • Overview

    Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]

  • Synonyms

    ADAM10;ADAM metallopeptidase domain 10;RAK;kuz;AD10;AD18;MADM;CD156c;HsT18717;disintegrin and metalloproteinase domain-containing protein 10;CDw156;kuzbanian protein homolog;mammalian disintegrin-metalloprotease;a disintegrin and metalloprotease domain 10

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Rat
  • Sf21 Insect Cell
  • Mammalian Cell
  • E.coli
  • Wheat Germ
  • HEK293
  • CHO
  • E. coli
  • E.coli expression system
  • His
  • GST
  • His&Fc&Avi
  • N-His&C-hFc
  • N-His
Cat.# Product name Source (Host) Species Tag Protein Length Price
ADAM10-18H Active Recombinant Human ADAM10, His-tagged Sf21 Insect Cell Human His 214-672 a.a.
ADAM10-924H Active Recombinant Human ADAM10 Protein, His-tagged Sf21 Insect Cell Human His Thr214-Glu672
Adam10-961M Active Recombinant Mouse Adam10 Protein, His-tagged Sf21 Insect Cell Mouse His Thr215-Glu673
ADAM10-1275M Recombinant Mouse ADAM10 Protein Mammalian Cell Mouse His
Adam10-1927M Recombinant Mouse Adam10, His-tagged Sf21 Insect Cell Mouse His 215-673 a.a.
ADAM10-265H Recombinant Human ADAM 10, His-tagged E.coli Human His 214-672 a.a.
ADAM10-272H Recombinant Human ADAM10 Protein, GST-tagged Wheat Germ Human GST
ADAM10-5834C Recombinant Chicken ADAM10 Mammalian Cell Chicken His
ADAM10-7638H Recombinant Human ADAM10 protein, His-tagged E.coli Human His Arg420~Val641
Adam10-7639R Recombinant Rat Adam10 protein, His-tagged E.coli Rat His Thr218~Asp445
ADAM10-0691H Recombinant Human ADAM10 Protein (Thr214-Ser504), N-His tagged E.coli Human His Thr214-Ser504
ADAM10-306M Recombinant Mouse ADAM10 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ADAM10-306M-B Recombinant Mouse ADAM10 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ADAM10-73H Recombinant Human ADAM10 Protein, His-tagged CHO Human His Thr214-Glu672
ADAM10-74H Recombinant Human ADAM10 protein, His-tagged HEK293 Human His Thr214~Glu672
ADAM10-75H Recombinant Human ADAM10 protein, His&hFc-tagged HEK293 Human N-His&C-hFc Arg420~Val641
MARCH9-785H Recombinant Human MARCH9 protein, His-tagged E. coli Human N-His 265-340 aa
RFL-28202HF Recombinant Full Length Human Disintegrin And Metalloproteinase Domain-Containing Protein 10(Adam10) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (214-748)

    Involved Pathway

    ADAM10 involved in several pathways and played different roles in them. We selected most pathways ADAM10 participated on our site, such as Activated NOTCH1 Transmits Signal to the Nucleus,Alzheimers disease,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance TRIO,RASGEF1A,CLTA,GNAI3,CLTC,NEFLB,ROBO2,ITSN1,SLIT1,COL4A3
    Activated NOTCH1 Transmits Signal to the Nucleus JAG1,CNTN1,JAG2,DLK1,MIB1,DNER,DTX2
    Constitutive Signaling by NOTCH1 PEST Domain Mutants HEY2,HEY1,HDAC5,CCNC,HDAC6,JAG1,HEYL,JAG2,MIB1,CDK8
    Alzheimers disease GAPDH,MAPK1,AKR1C1,UQCRB,ATP5O,IDE,NDUFA6,COX7B2,APH1B,COX7A2
    Collagen degradation MGC174152,CTSK,EMID2,MGC174857,CTSL1,CTSLL,MMP15,MMP13,COL15A1B,COL19A1
    Constitutive Signaling by NOTCH1 HD Domain Mutants JAG1,JAG2,MIB1
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HEY2,JAG1,HEY1,CCNC,HDAC5,CDK8,MIB1,HEYL,HDAC6,JAG2

    Protein Function

    ADAM10 has several biochemical functions, for example, SH3 domain binding,endopeptidase activity,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM10 itself. We selected most functions ADAM10 had, and list some proteins which have the same functions with ADAM10. You can find most of the proteins on our site.

    Function Related Protein
    metallopeptidase activity LNPEP,PSMD14,PAPPAA,PGCP,MEP1A.1,DNPEP,ADAM25,NPEPPS,ADAMTSL1,ADAM17A
    protein homodimerization activity BIRC5,AADAT,MID2,HES1,CRTAM,NFKB1,SYNDIG1,CDSN,TCF3A,TREX1
    metalloendopeptidase activity AFG3L2,MIPEP,MMP13A,MMP14,NPSN,YBEY,ADAMTS20,GM12824,MMP7,ADAM10B
    protein binding DAK,BCL2L10,TUBA3C,NCOA2,PIK3CB,EFNA1,DUSP12,NUDT12,CXCR2,CSTF2
    zinc ion binding TADA2B,ADAT2,TET1,ADAM5P,SPRYD5,ZC3HC1,KAT7A,WTIP,SRSF7,ADAMTS10
    SH3 domain binding ITGB1BP2,CBL,ARHGAP1,GRB2,FAM125A,BCAR1,DRD4,TOM1L1,SHANK1,PDE4D
    integrin binding NF2,S1PR2,ITGB1BP2,Tcam1,ICAM5,WISP1A,ICAM1,EDIL3,ADAM9,ADAM17
    endopeptidase activity KLK1B11,TPP2,KLK1B4,SENP5,APH1C,PSMB9B,PSMB5,KLK1B24,FAP,MMP9
    protein kinase binding AP2A1,CCNL2,SMAD3,SNAP91,PTPRR,TP53,RB1CC1,ZC3HC1,KCNA5,NPR1

    Interacting Protein

    ADAM10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM10.

    PDIA3;AR;PHB;btuB;pi3p;CD9

    Resources

    Research Area

    ADAMs on Endothelial Cells
    Notch Family
    Alzheimer's Disease
    Metalloproteases and Regulators
    E-Cadherin Ectodomain Shedding and Proteolytic Processing

    References

    • Martin, RK; Brooks, KB; et al. Antigen Transfer from Exosomes to Dendritic Cells as an Explanation for the Immune Enhancement Seen by IgE Immune Complexes. PLOS ONE 9:-(2014).
    • Sampedro, GR; DeDent, AC; et al. Targeting Staphylococcus aureus alpha-Toxin as a Novel Approach to Reduce Severity of Recurrent Skin and Soft-Tissue Infections. JOURNAL OF INFECTIOUS DISEASES 210:1012-1018(2014).

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