ACTN4
-
Official Full Name
actinin, alpha 4 -
Overview
The two major cytoskeletal proteins implicated in cell motility are actin and myosin. There are three a-actin (skeletal, cardiac, and smooth muscle), one b-actin (b ?nonmuscle), and two y-actins (y-smooth nuscle and y-nonmuscle). Antibody to b-actin provides a specific and useful tool in studying the intracellular distribution of b-actin and the static and dynamic aspects of the cytoskeleton. -
Synonyms
ACTN4;actinin, alpha 4;focal segmental glomerulosclerosis 1 , FSGS1;alpha-actinin-4;actinin alpha4 isoform;non-muscle alpha-actinin 4;F-actin cross-linking protein;focal segmental glomerulosclerosis 1;FSGS;FSGS1;ACTININ-4;DKFZp686K23158
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Bovine
- Rat
- Chicken
- Zebrafish
- E.coli
- E. coli
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- Wheat Germ
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- Mamanlian cells
- GST
- N-GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
- N-His
Involved Pathway
ACTN4 involved in several pathways and played different roles in them. We selected most pathways ACTN4 participated on our site, such as Focal adhesion,Adherens junction,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | FLNC,THBS4A,IGF1RB,BCAR1,COL6A3,VTN,ROCK1,PDGFRB,RAC1B,BCL2A |
| Regulation of Actin Cytoskeleton | ARPC5LA,ITGA5,PDGFB,MAP2K1,FGF17,ROCK2A,LIMK1A,ARHGEF12,HRASB,PAK3 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | CACNG4,DSG2,ITGB1,ATP2A2,Itga10&Itgb1,ITGB3,SGCD,TCF7L2,CACNG8,LAMA2 |
| Adherens junction | RHOA,RAC3A,MAPK1,FGFR1,VCL,RAC2,CTNNA3,CTNND1,PTPRFB,PARD3 |
| Tight junction | YBX3,PRKCG,CLDN11B,MYH1E,MYH8,NRAS,RAB3B,TJP2A,PPP2R1B,CTNNA3 |
| Viral carcinogenesis | HIST1H4A,STAT5A,TRAF3,HIST2H2BE,HLA-C,SND1,H2-Q10,RHOA,HIST1H4E,GTF2A2 |
| Leukocyte transendothelial migration | CYBA,CLDN1,CTNNA3,CLDN18,RHOA,CLDN6,RAC1,MMP9,ROCK1,CLDN4 |
| Amoebiasis | PIK3R2,RAB7B,RAB7,PLCB4,LAMC2,LAMC3,C8B,COL2A1,LAMB2,FN1 |
| Systemic lupus erythematosus | HIST1H2AN,GM6026,HIST1H2AG,HIST1H2BM,HLA-DRB5,GM14478,GRIN2B,HIST1H4H,C1S,HIST1H2BI |
Protein Function
ACTN4 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,actin binding,actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTN4 itself. We selected most functions ACTN4 had, and list some proteins which have the same functions with ACTN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein N-terminus binding | GLRX,KCNIP2,SCFD1,KCNIP1,TRAF6,ERCC3,STX5A,ERCC5,CHMP6,GTF2H2 |
| ligand-dependent nuclear receptor transcription coactivator activity | PPARGC1B,MED17,PSMC3IP,CARM1,MED30,USP22,FGF2,ATXN7L3,TSG101,CCAR1 |
| ion channel binding | PRKCSH,PHPT1,FAM115A,LRRK2,FGF12,PKP2,PDE4D,SLC8A1,SNTA1,RIMS3 |
| protein binding | C16orf59,NBN,ALPI,FCRL4,FBXO5,ZKSCAN4,PAX9,Chrng,RAB14,TSNAX |
| protein homodimerization activity | TIMM10,LDB1,CRYM,BHLHA15,FLNA,BARD1,ABP1,NTRK2,ALDH5A1,PRPS1L1 |
| nucleoside binding | AASS,CDA,PNP,POLA1 |
| calcium ion binding | TTN,JAG1B,S100A8,MMP13,MMP14B,PCDHGA2,SNCB,MMP20,PCLO,CDHR1 |
| integrin binding | CYR61L1,ICAM3,COL4A3,ADAM23,PXN,S1PR3,ITGA6,KDR,TSPAN4,ADAM17 |
| retinoic acid receptor binding | LRIF1,HMGA1,PRAME,CNOT1,PRAMEF6,MED25,PRAMEF10,ASXL1,PRAMEF1,AASS |
Interacting Protein
ACTN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTN4.
MYOZ2;CTNNB1;IQGAP1;TJP1
Resources
Related Services
Related Products
References
- Yoshii, H; Ito, K; et al. Increased expression of alpha-actinin-4 is associated with unfavorable pathological features and invasiveness of bladder cancer. ONCOLOGY REPORTS 30:1073-1080(2013).
- Kimura, J; Ichii, O; et al. Close Relations between Podocyte Injuries and Membranous Proliferative Glomerulonephritis in Autoimmune Murine Models. AMERICAN JOURNAL OF NEPHROLOGY 38:27-38(2013).
