ACTL7A
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Official Full Name
actin-like 7A -
Overview
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. -
Synonyms
ACTL7A;actin-like 7A;actin-like protein 7A;actin-like 7-alpha;actin-like-7-alpha
Recombinant Proteins
- Mouse
- Human
- Cynomolgus
- Rat
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- His&SUMO
- His&Fc&Avi
Involved Pathway
ACTL7A involved in several pathways and played different roles in them. We selected most pathways ACTL7A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTL7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ACTL7A has several biochemical functions, for example, protein binding,structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTL7A itself. We selected most functions ACTL7A had, and list some proteins which have the same functions with ACTL7A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of cytoskeleton | DSP,TUBA2,ACTL7B,TUBB4A,AGRN,TUBE1,SPRR2A1,TUBB6,SPTBN2,ARPC4 |
| protein binding | CAMTA2,UBXN2B,LRIF1,TBX18,ARHGAP9,TNFAIP8L2,KCNN4,SFN,BLOC1S2A,ALPL |
Interacting Protein
ACTL7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTL7A here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTL7A.
TES;ENAH
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