ACTG2
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Official Full Name
actin, gamma 2, smooth muscle, enteric -
Overview
Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the;cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are;found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist;in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes;actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript;variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of;this gene is formed by removal of two N-terminal peptides. -
Synonyms
ACTG2;actin, gamma 2, smooth muscle, enteric;ACTA3, ACTL3;actin, gamma-enteric smooth muscle;ACTSG;alpha-actin 3;alpha-actin-3;gamma-2-actin;actin-like protein;smooth muscle gamma actin;smooth muscle gamma-actin;ACT;ACTE;ACTA3;ACTL3
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
ACTG2 involved in several pathways and played different roles in them. We selected most pathways ACTG2 participated on our site, such as Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vascular smooth muscle contraction | PLA2G2E,PRKG1A,CALD1B,AGTR1B,MYL6,CALM1B,AGTR1A,PRKCBB,PLA2G4A,ADCY2B |
Protein Function
ACTG2 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTG2 itself. We selected most functions ACTG2 had, and list some proteins which have the same functions with ACTG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| helicase activity | MOV10,DHX57,SNRNP200,PL10,NAV2,SMARCAL1,DICER1,SHPRH,WRN,IFIH1 |
| hydrolase activity | SNRNP200,PPM1E,SIRT3,GBP3,ABHD14A,PPP1CAB,Ren1,ABHD16A,CES1D,PLA2G4AA |
| ATP binding | MARK4,BMPR1AA,DCLK2,PCXA,ACSS1,DGKE,PKZ,MAPK12B,SLC27A2,HIPK1 |
| nucleotide binding | CKMT2A,RBM28,SRSF7,RAB35B,KIF4,RAC3A,PPARGC1A,RBM33,RBMY1F,RBPMS2 |
| ATP-dependent RNA helicase activity | DDX20,DDX49,DDX39B,DDX56,DHX33,SNRNP200,DDX59,DHX9,DHX37,DDX43 |
| nucleic acid binding | ZFP367,KLF2A,ZFP523,GLIS3,ZFP473,SCAND3,EGR2A,KHDRBS1B,SYNCRIPL,TSEN34 |
Interacting Protein
ACTG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTG2.
MLH1;UL36;15-deoxy-delta(12,14;NS1;US11;ARRB2;VP24;RL1;GRB2;NS1
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References
- Wangler, MF; Gonzaga-Jauregui, C; et al. Heterozygous De Novo and Inherited Mutations in the Smooth Muscle Actin (ACTG2) Gene Underlie Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome. PLOS GENETICS 10:-(2014).
- Lehtonen, HJ; Sipponen, T; et al. Segregation of a Missense Variant in Enteric Smooth Muscle Actin gamma-2 With Autosomal Dominant Familial Visceral Myopathy. GASTROENTEROLOGY 143:1482-+(2012).
