ACSL3
-
Official Full Name
acyl-CoA synthetase long-chain family member 3 -
Overview
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
ACSL3;acyl-CoA synthetase long-chain family member 3;FACL3, fatty acid Coenzyme A ligase, long chain 3;long-chain-fatty-acid--CoA ligase 3;ACS3;PRO2194;LACS 3;lignoceroyl-CoA synthase;long-chain acyl-CoA synthetase 3;fatty-acid-Coenzyme A ligase
Recombinant Proteins
- Mouse
- Human
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- E. coli
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- N-His
Involved Pathway
ACSL3 involved in several pathways and played different roles in them. We selected most pathways ACSL3 participated on our site, such as Fatty acid biosynthesis,Fatty acid degradation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid metabolism | MCAT,ACAT2,Scd1,ACAA2,MECR,ACSL3A,FASN,ACADL,ACSL4A,ACSL3B |
| Fatty Acid Biosynthesis | OLAH,ACACB,ACSL4A,MCAT,ACSL5,ACSL4B,ACACA,ECH1,ACSL4,ACSBG1 |
| Peroxisome | AGPS,NUDT7,PEX3,ACAA1A,PECI,CRAT,PRDX1,NUDT19,CAT,MPV17L |
| Adipocytokine signaling pathway | PRKAA1,NFKBIE,PRKAB2,RXRGA,ADIPOR2,PRKAB1A,NFKBIB,TRADD,JAK2B,NFKBIAB |
| Fatty acid degradation | ALDH2,ALDH9A1,ADH5,ACSBG1,CPT2,ADH1B,ALDH7A1,ADH2-1,HADHB,ACADVL |
| PPAR signaling pathway | FABP2,SCDB,PLTP,RXRAA,SLC27A1B,ACSBG1,ACSL1,ACAA1A,FABP1,CYP4A12A |
| Metabolic pathways | AZIN2,LCT,XDH,ALDH2,ALDOCA,ADKA,CSGALNACT1,AGXT2,NDUFB11,OGDH |
Protein Function
ACSL3 has several biochemical functions, for example, ATP binding,long-chain fatty acid-CoA ligase activity,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL3 itself. We selected most functions ACSL3 had, and list some proteins which have the same functions with ACSL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | EFS,YWHAQ,HMGB2,HIST1H4H,PTPN11,SCN5A,ERCC1,XPO1,DRD3,YWHAE1 |
| ATP binding | WNK2,GRK6,DMC1,RPS6KB1B,ACTR2A,ITPK1A,GLUD1,TTLL4,KIF23,CHKA |
| long-chain fatty acid-CoA ligase activity | SLC27A4,ACSBG1,SLC27A2,SLC27A1B,ACSBG2,SLC27A1A,SLC27A5,ACSL5,SLC27A3,ACSL4 |
| protein kinase binding | AGAP2,SYN1,NEK9,RPS3,GSK3B,RAD9A,TSACC,FBXW5,TUBB3,PPP1R12B |
Interacting Protein
ACSL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL3.
vpu;GTF2F2;NDRG1;Chek1;ACSL4;PPP6R2;EGFR;1C;ERBB2;KIF11;REEP5;TIGD6;TMEM173;SPG20;HIPK4;SKA1;KIF20B;Rassf1
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