ACSL1
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Official Full Name
acyl-CoA synthetase long-chain family member 1 -
Overview
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] -
Synonyms
ACSL1;acyl-CoA synthetase long-chain family member 1;ACS1;LACS;FACL1;FACL2;LACS1;LACS2;long-chain-fatty-acid--CoA ligase 1;LACS 1;LACS 2;acyl-CoA synthetase 1;palmitoyl-CoA ligase 1;palmitoyl-CoA ligase 2;paltimoyl-CoA ligase 1;lignoceroyl-CoA synthase;long-chain acyl-CoA synthetase 1;long-chain acyl-CoA synthetase 2;long-chain fatty acid-CoA ligase 2;long-chain fatty-acid-coenzyme A ligase 1;fatty-acid-Coenzyme A ligase, long-chain 1;fatty-acid-Coenzyme A ligase, long-chain 2
Recombinant Proteins
- Mouse
- Chicken
- Human
- Rat
- Mus musculus
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- His
- GST
- Avi
- Fc
- Non
- DDK
- Myc
Involved Pathway
ACSL1 involved in several pathways and played different roles in them. We selected most pathways ACSL1 participated on our site, such as Fatty acid biosynthesis,Fatty acid degradation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipocytokine signaling pathway | RXRBA,ADIPOR2,TNF,CPT1C,LEPR,NFKBIAA,G6PC,ACSL3B,PTPN11,IRS1 |
| Fatty Acid Biosynthesis | ACSBG1,ECH1,ACSL3A,ECHDC2,ACSL4,ACSL1A,ACAA2,ACSL5,FASN,MCAT |
| Peroxisome | SLC25A17,PEX16,ACSL4A,DECR2,IDH1,DAO.1,ABCD4,PEX12,PRDX5,ACSL5 |
| Metabolic pathways | POLE,CYP2C39,COQ2,PKM2,ALDH2.1,MAT2AB,DAD1,CYP2C19,EXT1C,Aldh1a7 |
| PPAR signaling pathway | PDPK1,UCP1,FABP7,SLC27A1A,GK2,ACSL3A,ACSL4B,RXRA,SLC27A4,PCK1 |
| Fatty acid degradation | ACSL4B,ACADVL,ACSL3A,ACSBG1,ADH1C,ACSBG2,ACAA1A,EHHADH,ADH2-1,ALDH9A1B |
| Fatty acid metabolism | PTPLAD1,PPT1,FASN,SCD,CPT2,MECR,HADHB,ACADS,ACSL1A,ACSBG2 |
Protein Function
ACSL1 has several biochemical functions, for example, ATP binding,acetate-CoA ligase (ADP-forming) activity,catalytic activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL1 itself. We selected most functions ACSL1 had, and list some proteins which have the same functions with ACSL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| long-chain fatty acid-CoA ligase activity | SLC27A2,SLC27A1B,ACSL4,ACSL3,ACSBG2,SLC27A4,ACSL5,SLC27A5,SLC27A3,ACSBG1 |
| catalytic activity | DBH,SYN2,PFKFB2A,ISOC2,SPTLC3,TIGARB,PPM1BB,SULF2A,NDUFA9A,PPM1BA |
| ligase activity | BIRC3,UBE2KB,MARCH6,BRAP,GLULB,PJA1,RNF43,RNF111,CBX4,CCNB1IP1 |
| nucleotide binding | LTK,TRA2A,RIPK4,DCLK2,UBE2NB,MAP2K4A,SBK3,TRA2B,ADCY1A,GNA12A |
| ATP binding | SPATA5L1,ACTR1A,PTK2,VRK2,PTK6,PKZ,BBS10,RAD51B,KIF19,PSMC5 |
Interacting Protein
ACSL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL1.
Pgrmc1;CYP2C2;Ephx1;Cyp2d10;Hsd11b1;Ywhae;Ywhaz;Fmo5
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