ACO2
-
Official Full Name
aconitase 2, mitochondrial -
Overview
Aconitase 2 (ACO2) catalyzes the conversion of citrate to isocitrate via cis-aconitate in the second step of the tricarboxylic acid (TCA) cycle. ACO2 also is an important regulator of iron homeostasis within cells. In addition, this enzyme is found to be -
Synonyms
ACO2;aconitase 2, mitochondrial;aconitate hydratase, mitochondrial;ACONM;citrate hydro-lyase;ICRD;MGC20605;MGC33908
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- Insect Cells
- Insect Cell
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- His
- GST
- His&GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
ACO2 involved in several pathways and played different roles in them. We selected most pathways ACO2 participated on our site, such as Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| -Oxocarboxylic acid metabolism | GPT2L,BCAT1,AADAT,IDH3A,IDH2,ACO1,GOT2A,GOT2,GOT2B,GPT |
| Glyoxylate and dicarboxylate metabolism | AGXTB,GCSHB,SHMT1,MUT,ACAT1,GRHPR,PCCB,AMT,AGXTA,GCSHA |
| Citrate cycle (TCA cycle) | DLD,DLST,SUCLG2,PDHA2,IDH3A,PDHA1,IDH1,SDHDB,PCXB,PDHA1A |
| Biosynthesis of amino acids | OTC,TKTL1,GOT2A,pykF,ALDH18A1,PRPS1L1,TKTB,PKM2,GLULC,TPI1B |
| Metabolic pathways | UCKL1,ADH4,NOS3,ITPKA,DPYS,PFAS,OXSR1,PIP5KL1,PCK1,POLG2 |
| Carbon metabolism | ESD,PRPS1A,ENO1,ME2,ME3,FH1,GPI1,ENO2,HK3,DLST |
Protein Function
ACO2 has several biochemical functions, for example, 3 iron, 4 sulfur cluster binding,4 iron, 4 sulfur cluster binding,aconitate hydratase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACO2 itself. We selected most functions ACO2 had, and list some proteins which have the same functions with ACO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | HBE1,CYP2AA4,CYP2C18,CYP11B1,CYP2R1,CYP2C70,EGLN1,CYP26A1,TMEM195,CYP26C1 |
| 4 iron, 4 sulfur cluster binding | LIAS,POLE,SDHB,ISCUB,POLA1,DEM1,ETFDH,RTEL1,DPYD,NUBP2 |
| 3 iron, 4 sulfur cluster binding | SDHB |
| aconitate hydratase activity | ACO1 |
Interacting Protein
ACO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACO2.
VCAM1;MLH1;ere_dna;CLPP
Resources
Related Services
Related Products
References
- Du, Z; McManus, MT; et al. Identification of proteins in leaf tissues of white clover using MALDI-TOF mass spectrometry. BIOLOGIA PLANTARUM 55:261-268(2011).
- Du, ZN; Leung, S; et al. ACC oxidase (ACO) genes in Trifolium occidentale (L.) and their relationship to ACO genes in white clover (T. repens L.) and T. pallescens (L.). PLANT PHYSIOLOGY AND BIOCHEMISTRY 49:420-426(2011).
