ACADVL
-
Official Full Name
acyl-CoA dehydrogenase, very long chain -
Overview
The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
ACADVL;acyl-CoA dehydrogenase, very long chain;acyl Coenzyme A dehydrogenase, very long chain;very long-chain specific acyl-CoA dehydrogenase, mitochondrial;ACAD6;LCACD;VLCAD;acyl-Coenzyme A dehydrogenase, very long chain
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ACADVL-11890Z | Recombinant Zebrafish ACADVL | Mammalian Cell | Zebrafish | His |
|
|
| ACADVL-138H | Recombinant Human ACADVL Protein, GST-Tagged | Wheat Germ | Human | GST |
|
|
| ACADVL-139H | Recombinant Human ACADVL Protein, GST-Tagged | Wheat Germ | Human | GST |
|
|
| ACADVL-26050TH | Recombinant Human ACADVL, His-tagged | E.coli | Human | His | 615 amino acids |
|
| ACADVL-440R | Recombinant Rat ACADVL Protein | Mammalian Cell | Rat | His |
|
|
| ACADVL-785H | Recombinant Human ACADVL, His-tagged | E.coli | Human | His |
|
|
| ACADVL-9111HCL | Recombinant Human ACADVL 293 Cell Lysate | HEK293 | Human | Non |
|
|
| ACADVL-27H | Recombinant Human ACADVL Protein, His-tagged | E.coli | Human | His | Ala408-Phe655 |
|
| Acadvl-28M | Recombinant Mouse Acadvl Protein, His-tagged | E.coli | Mouse | His | Ile421-Ile656 |
|
| Acadvl-504M | Recombinant Mouse Acadvl Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| ACADVL-911HF | Recombinant Full Length Human ACADVL Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 655 amino acids |
|
| ACADVL-95R | Recombinant Rat ACADVL Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| ACADVL-95R-B | Recombinant Rat ACADVL Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
Involved Pathway
ACADVL involved in several pathways and played different roles in them. We selected most pathways ACADVL participated on our site, such as Fatty acid degradation,Metabolic pathways,Fatty acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACADVL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GGT5A,CHKB,IDH1,GLCE,AKR1C3,DNMT3A,QDPRB1,SYNJ2,CYP2C45,B3GNT4 |
| Fatty acid degradation | ALDH9A1,ACADL,ECI2,ACSL1A,HADHAA,CYP4A11,ACADS,ACAA2,PECI,ACSL3A |
| Fatty acid metabolism | PTPLA,SCD,Scd2,HADHAB,ACSL4B,FADS1,ACSL3,ACAA1A,MCAT,SCDB |
Protein Function
ACADVL has several biochemical functions, for example, acyl-CoA dehydrogenase activity,electron carrier activity,fatty-acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACADVL itself. We selected most functions ACADVL had, and list some proteins which have the same functions with ACADVL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| electron carrier activity | GRX2,GLRX5,GLRX2,DHRS3,AOX4,AKR1B1,COX7A2A,GCDHA,TXNRD1,ACOX3 |
| acyl-CoA dehydrogenase activity | ETFA,ACADM,ACOX1,ACADSB,ACOX2,ACOX3,ACAD9,ACADS,GCDHB,ACAD8 |
| fatty-acyl-CoA binding | ACBD7,IVD,ALDH6A1,ACOX2,HADHA,SCP2,HMGCL,ACOX1,ECI2,ACAD9 |
| long-chain-acyl-CoA dehydrogenase activity | ACAD11,ACADL |
| oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | ACOXL,ACAD11,GCDHB,GCDH,ACOX1,ACADM,IVD,ACAD9,ACADL,ETFA |
| flavin adenine dinucleotide binding | DMGDH,MAOB,DUS4L,CHDH,GULO,SQLEA,GCDHA,DUS1L,AIFM2,MTO1 |
| very-long-chain-acyl-CoA dehydrogenase activity | ACAD11,RSAD1 |
Interacting Protein
ACADVL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACADVL here. Most of them are supplied by our site. Hope this information will be useful for your research of ACADVL.
CDH1;RPSA;GPHN;KIF2A;EEF2K;DENR;ALB;CDK1;ATF2;EIF4A3;METAP2;CKAP5;ICT1;Ncbp2;PA2G4;SIRT4
Resources
Related Services
Related Products
References
- Kabuyama, Y; Suzuki, T; et al. Dysregulation of very long chain acyl-CoA dehydrogenase coupled with lipid peroxidation. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 298:C107-C113(2010).
- Merrittll, JL; Nguyen, T; et al. Biochemical Correction of Very Long-chain Acyl-CoA Dehydrogenase Deficiency Following Adeno-associated Virus Gene Therapy. MOLECULAR THERAPY 17:425-429(2009).
