ACAA2
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Official Full Name
acetyl-CoA acyltransferase 2 -
Overview
The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. -
Synonyms
ACAA2;acetyl-CoA acyltransferase 2;acetyl Coenzyme A acyltransferase 2;3-ketoacyl-CoA thiolase, mitochondrial;DSAEC;mitochondrial 3 oxoacyl Coenzyme A thiolase;T1;beta ketothiolase;beta-ketothiolase;acetyl-Coenzyme A acyltransferase 2;mitochondr
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Yeast
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- GST
- His
- His&T7
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ACAA2 involved in several pathways and played different roles in them. We selected most pathways ACAA2 participated on our site, such as Biosynthesis of antibiotics,Fatty Acid Biosynthesis,Fatty acid degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biosynthesis of antibiotics | CTH,SDS,NME6,pykF,UAP1L1,DBT,LDHAL6A,AGXT,GLYCTK,AK7 |
| Fatty acid metabolism | HADHA,ACADM,ACADSB,ELOVL6,HADH,ACAT1,TECR,PPT2,PTPLAD1,ACSL3A |
| Valine, leucine and isoleucine degradation | HADHA,ALDH2.2,MCCC1,BCAT1,ACAD8,ACSF3,OXCT2,ALDH1B1,HMGCL,HADHB |
| Fatty acid elongation | PTPLAD2,PPT1,ELOVL4A,ELOVL4,TECR,HADH,ACOT7,HADHAA,HADHB,HADHAB |
| Fatty acid biosynthesis | ACSL4A,ACSBG1,MCAT,ECHDC3,ACSL3,FASN,ACSL4B,ACACB,ACSL1,ACSL4 |
| bile acid biosynthesis, neutral pathway | POR |
| Metabolic pathways | COQ3,LPIN1,GANC,NME4,PTGS2A,NFS1,HK3,ALDOC,NMNAT2,ACMSD |
| Fatty acid degradation | EHHADH,CYP4A11,PECI,ACSL1B,ADH5,HADHAA,ECI1,ADH2-1,ACSBG2,CYP4A12A |
Protein Function
ACAA2 has several biochemical functions, for example, acetyl-CoA C-acyltransferase activity,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAA2 itself. We selected most functions ACAA2 had, and list some proteins which have the same functions with ACAA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | HNRPLL,NVL,TDRD9,LSM2,CAPRIN1,RPS17L,RBM7,ERAL1,IGF2BP2,CISD2 |
| acetyl-CoA C-acyltransferase activity | ACAA1,ACAA1A,HADHB |
| protein binding | KLHL2,MST1R,PRKD2,ZFP110,GATA6,GIT2,CDH1,CREB5,PLK1S1,TDRKH |
Interacting Protein
ACAA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAA2.
LAMTOR5;fliG;ARMC6
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References
- Carrier, B; Wen, S; et al. Alpha-Lipoic Acid Reduces LDL-Particle Number and PCSK9 Concentrations in High-Fat Fed Obese Zucker Rats. PLOS ONE 9:-(2014).
- Baghel, AS; Tandon, R; et al. Characterization of protein acyltransferase function of recombinant purified GlnA1 from Mycobacterium tuberculosis: A moon lighting property. MICROBIOLOGICAL RESEARCH 166:662-672(2011).
