ABHD5
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Official Full Name
abhydrolase domain containing 5 -
Overview
The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. -
Synonyms
ABHD5;abhydrolase domain containing 5;1-acylglycerol-3-phosphate O-acyltransferase ABHD5;CGI 58;NCIE2;lipid droplet-binding protein CGI-58;abhydrolase domain-containing protein 5;CDS;CGI58;IECN2;MGC8731
Recombinant Proteins
- Mouse
- Rhesus macaque
- Rat
- Chicken
- Human
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- His&SUMO
- Flag
Involved Pathway
ABHD5 involved in several pathways and played different roles in them. We selected most pathways ABHD5 participated on our site, such as Regulation of lipolysis in adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABHD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of lipolysis in adipocytes | GNAS,PIK3CB,GNAI1,PIK3CG,PRKACG,PRKG2,PTGS2,PDE3B,NPY1R,IRS2 |
Protein Function
ABHD5 has several biochemical functions, for example, 1-acylglycerol-3-phosphate O-acyltransferase activity,carboxylic ester hydrolase activity,lysophosphatidic acid acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABHD5 itself. We selected most functions ABHD5 had, and list some proteins which have the same functions with ABHD5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carboxylic ester hydrolase activity | Aadacl3,ABHD2B,FAM135A,NCEH1A,LIPCA,ACOT10,LIPI,ABHD11,CES1C,CES1 |
| 1-acylglycerol-3-phosphate O-acyltransferase activity | AGPAT9,AGPAT4,AGPAT9L,LCLAT1,AGPAT2,LYCAT,AGPAT5,AGPAT1,LPCAT2,AGPAT3 |
Interacting Protein
ABHD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABHD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABHD5.
Dlg4;q81sn0_bacan;q81y62_bacan
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References
- Stelmanska, E; Szrok, S; et al. Progesterone-induced down-regulation of hormone sensitive lipase (Lipe) and up-regulation of G0/G1 switch 2 (G0s2) genes expression in inguinal adipose tissue of female rats is reflected by diminished rate of lipolysis. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 147:31-39(2015).
- Jebessa, ZH; Worst, B; et al. Protein Kinase A prevents cardiomyocyte hypertrophy through abhydrolase domain containing 5 (ABHD5)-mediated proteolysis of Histone deacetylase 4(HDAC4). CIRCULATION RESEARCH 113:-(2013).
