ABHD4
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Official Full Name
abhydrolase domain containing 4 -
Overview
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine. -
Synonyms
ABHD4;abhydrolase domain containing 4;abhydrolase domain-containing protein 4;FLJ12816;alpha/beta-hydrolase 4;lyso-N-acylphosphatidylethanolamine lipase;ABH4
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Insect Cells
- Wheat Germ
- Mammalian Cell
- Insect Cell
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ABHD4-3337H | Recombinant Human ABHD4 protein, His-tagged | Insect Cells | Human | His | Met1-Asp342 | |
| ABHD4-078H | Recombinant Human ABHD4 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| ABHD4-191R | Recombinant Rhesus monkey ABHD4 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| ABHD4-2384Z | Recombinant Zebrafish ABHD4 | Mammalian Cell | Zebrafish | His |
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| ABHD4-675HCL | Recombinant Human ABHD4 cell lysate | Insect Cell | Human | Non |
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| ABHD4-20R | Recombinant Rhesus Macaque ABHD4 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ABHD4-20R-B | Recombinant Rhesus Macaque ABHD4 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| ABHD4-878HF | Recombinant Full Length Human ABHD4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 342 amino acids |
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Involved Pathway
ABHD4 involved in several pathways and played different roles in them. We selected most pathways ABHD4 participated on our site, such as Glycerophospholipid biosynthesis,Hydrolysis of LPE,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABHD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | NAGS,B3GAT2,CYP19A1,MARCKSA,AQP1A.2,PPM1L,ARL2BP,SLC26A1,DSEL,FABP12 |
| Metabolism of lipids and lipoproteins | ARSH,CPNE6,GLTP,MED7,ARSI,ACOT9,PLBD1,MTF1,CERS4A,PTGDSA |
| Phospholipid metabolism | AWAT2,PLBD1,CEPT1,CHKB,PITPNB,CEPT1A,SACM1LB,CPNE3,PTPMT1,ARF3 |
| Glycerophospholipid biosynthesis | CPNE1,CPNE3,STIL,PLBD1,PHOSPHO1,GPAT2,ABHD3,PNPLA8,PTPMT1,PEMT |
Protein Function
ABHD4 has several biochemical functions, for example, carboxylic ester hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABHD4 itself. We selected most functions ABHD4 had, and list some proteins which have the same functions with ABHD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carboxylic ester hydrolase activity | LIPH,ACOT10,FAM135B,CES1,Ces2c,AADACL2,NCEH1,ABHD11,ABHD2B,NOTUM1A |
Interacting Protein
ABHD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABHD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABHD4.
TK1;CSNK2B
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References
- Jebessa, ZH; Worst, B; et al. Protein Kinase A prevents cardiomyocyte hypertrophy through abhydrolase domain containing 5 (ABHD5)-mediated proteolysis of Histone deacetylase 4(HDAC4). CIRCULATION RESEARCH 113:-(2013).
- Demiralp, DO; Haznedaroglu, IC; et al. Functional proteomic analysis of Ankaferd (R) Blood Stopper. TURKISH JOURNAL OF HEMATOLOGY 27:70-77(2010).
