ABHD12
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Official Full Name
abhydrolase domain containing 12 -
Overview
This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. -
Synonyms
ABHD12;abhydrolase domain containing 12;C20orf22, chromosome 20 open reading frame 22;monoacylglycerol lipase ABHD12;ABHD12A;BEM46L2;dJ965G21.2;DKFZP434P106;6330583M11Rik;AI431047;AW547313;RP23-241M12.2;Abhydrolase domain containing protein 12;C20orf22;2-arachidonoylglycerol hydrolase;abhydrolase domain-containing protein 12;PHARC
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Cynomolgus
- Rat
- Zebrafish
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Wheat Germ
- Mammalian Cell
- Mammalian cells
- HEK293T
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ABHD12 involved in several pathways and played different roles in them. We selected most pathways ABHD12 participated on our site, such as Arachidonate production from DAG,Effects of PIP2 hydrolysis,G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABHD12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gastrin-CREB signalling pathway via PKC and MAPK | DGKQ,TAC2,GRP,UTS2D,ABHD6B,ANXA1A,NMUR1,GCGA,OPN4A,EDNRAB |
| Hemostasis | KIFAP3,AKAP1,ANXA2,F13A1A.1,SLC7A11,MMRN1,HBG2,KIF15,KIF4,CFD |
| Platelet activation, signaling and aggregation | PLEK,SCG3,F13A1B,CD9A,CALU,PRKCHB,STXBP3,CLU,SPARC,MMRN2A |
| G alpha (q) signalling events | PROKR1A,RGS18,TAC1,HCRT,CYSLTR1,DGKQ,OPN4.1,LPAR2B,OPN4A,TRH |
| Signal Transduction | KLHL12,FMNL3,CDC42EP3,PENK,JUPA,METAP2B,GPBAR1,NMB,RGR,ARHGAP29 |
| GPCR downstream signaling | CHRM5,CXCL11.8,CCR7,S1PR3,PMCH,CALCA,ARHGEF1A,SSTR2,GPR132B,TAS2R13 |
| Effects of PIP2 hydrolysis | DGKQ,PRKCHB,ABHD6B,TRPC7,DGKG,MGLL,DGKA,DGKB,TRPC6A,TAE1 |
| Arachidonate production from DAG | ABHD6B,MGLL |
Protein Function
ABHD12 has several biochemical functions, for example, acylglycerol lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABHD12 itself. We selected most functions ABHD12 had, and list some proteins which have the same functions with ABHD12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acylglycerol lipase activity | PNLIPRP2,MGLL,ABHD6,FAAH |
Interacting Protein
ABHD12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABHD12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABHD12.
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References
- Kamat, SS; Camara, K; et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. NATURE CHEMICAL BIOLOGY 11:164-U116(2015).
- Wortmann, SB; Espeel, M; et al. Inborn errors of metabolism in the biosynthesis and remodelling of phospholipids. JOURNAL OF INHERITED METABOLIC DISEASE 38:99-110(2015).
