ABCG2
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Official Full Name
ATP-binding cassette, sub-family G (WHITE), member 2 -
Overview
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] -
Synonyms
ABCG2;ATP-binding cassette, sub-family G (WHITE), member 2;MRX;MXR;ABCP;BCRP;BMDP;MXR1;ABC15;BCRP1;CD338;GOUT1;CDw338;UAQTL1;EST157481;ATP-binding cassette sub-family G member 2;urate exporter;ABC transporter;placenta specific MDR protein;breast cancer resistance protein;ATP-binding cassette transporter G2;mitoxantrone resistance-associated protein;placenta-specific ATP-binding cassette transporter;multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Bovine
- Sus scrofa (Pig)
- Macaca mulatta
- Mus musculus
- Wheat Germ
- Mammalian Cells
- E.coli
- Insect Cells
- Yeast
- HEK293
- Non
- GST
- His
- His&T7
- EGFP&His&Strep II
- His&Myc
- Avi&Fc&His
Involved Pathway
ABCG2 involved in several pathways and played different roles in them. We selected most pathways ABCG2 participated on our site, such as ABC transporters,Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCB8,ABCB3L1,ABCB1,TAP2,ABCC5,ABCA4,Abcb1b,ABCA1,ABCD1,ABCB11 |
| Bile secretion | ADCY7,PRKACG,ABCC2,BAAT,NR0B2,AQP8,OSTA,SLCO1A5,SLC51B,AQP9 |
Protein Function
ABCG2 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances,heme transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCG2 itself. We selected most functions ABCG2 had, and list some proteins which have the same functions with ABCG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | IGJ,QDPR,HMGCS1,ODZ4,DPP4,LRRK2,SP100,PVR,XBP1,PITX2 |
| ATP binding | FARSB,MTHFD1L,PRKD3,HSPA4A,MAPK14,CCT7,MARK1,MARS2,MAP3K8,PRKCD |
| protein binding | SLC22A3,CDK7,SRC,CASP9,PHAX,VIP,GRASP,AVPI1,NCOR1,NPM1 |
| xenobiotic-transporting ATPase activity | ABCB4,Abcb1b,ABCB1A,ABCB1 |
| heme transporter activity | ABCB7,HRG-1,FLVCR1,MFSD7C,SLC48A1A,MFSD7B,HPX,SLC48A1B,SLC48A1 |
| ATPase activity, coupled to transmembrane movement of substances | ABCA5,ABCG3,ABCC10,ABCG5,ABCG2A,ABCC6,ABCA13,ABCA8,ABCD3,ABCB8 |
| transporter activity | PTGDSA,CRABP2A,SLC22A17,SEC22A,SLC2A1A,SLC2A15B,MFSD10,RBP1,SLC25A38B,ATP5B |
Interacting Protein
ABCG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCG2.
PIM1;UBC;Trim69
Resources
Research Area
Uptake and Transport Molecules on Endothelial CellsCardiac Stem Cell Markers
Muscle Stem Cell Markers
Myogenesis Markers
Blood-brain Barrier Transporters
Hematopoietic Stem Cell Markers
Embryonic and Induced Pluripotent Stem Cell Markers
Retinal Stem Cell Markers
Neural Stem Cell Markers
Head and Neck Cancer Stem Cell Markers
Lung Cancer Stem Cell Markers
Melanoma Cancer Stem Cell Markers
Osteosarcoma Cancer Stem Cell Markers
Prostate Cancer Stem Cell Markers
Glioma/Medulloblastoma Cancer Stem Cell Markers
Myogenic Precursor Markers
Osteosarcoma Biomarkers
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References
- Zhao, MC; Zhang, YS; et al. Hypoxia-induced cell stemness leads to drug resistance and poor prognosis in lung adenocarcinoma. LUNG CANCER 87:98-106(2015).
- Diaz-Torne, C; Perez-Herrero, N; et al. New medications in development for the treatment of hyperuricemia of gout. CURRENT OPINION IN RHEUMATOLOGY 27:164-169(2015).
