ABCE1
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Official Full Name
ATP-binding cassette, sub-family E (OABP), member 1 -
Overview
ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumor cell proliferation and antiapoptosis. -
Synonyms
RLI;OABP;ABC38;RNS4I;RNASEL1;RNASELI;ATP-binding cassette, sub-family E (OABP), member 1;ABCE1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rhesus macaque
- E.coli
- E. coli
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- His
- N-His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
- GST
Involved Pathway
ABCE1 involved in several pathways and played different roles in them. We selected most pathways ABCE1 participated on our site, such as ABC-family proteins mediated transport,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC-family proteins mediated transport | ABCA8,EIF2S1,EIF2S1A,EIF2S3,ABCF1,ABCA7,ABCG4B,ABCC2,ABCA4A,ABCC9 |
| Transmembrane transport of small molecules | SLC2A15B,SLC38A3,SLC43A1B,SLC39A14,SLC12A1,SLC36A2,SLC1A4,TRPC4AP,TRPM1A,ABCB8 |
Protein Function
ABCE1 has several biochemical functions, for example, ATP binding,ATPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCE1 itself. We selected most functions ABCE1 had, and list some proteins which have the same functions with ABCE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase activity | NSFB,OLA1,IDE,DNAH11,CARNS1,NSF,HSPA5,KIF27,MYH8,Abca2 |
| ATP binding | P2RY4,RIPK4,KIF7,ADCY8,NLRP5,PIF1,IRAK3,ATAD5,PIK3C2G,RAD17 |
| ribonuclease inhibitor activity | RNH1 |
| protein binding | SLC25A5,MLLT10,MCC,KRTAP19-5,AKAP13,EIF2S1,PPIB,PTPRD,KIF6,EZR |
Interacting Protein
ABCE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCE1.
gag;M;EIF3H;USP50;Kif13b;Cdc6;XRCC5;VCAM1;Brca1;ILK;LRRK2;Sidt2
Resources
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References
- Karblane, K; Gerassimenko, J; et al. ABCE1 Is a Highly Conserved RNA Silencing Suppressor. PLOS ONE 10:-(2015).
- Muhs, M; Hilal, T; et al. Cryo-EM of Ribosomal 80S Complexes with Termination Factors Reveals the Translocated Cricket Paralysis Virus IRES. MOLECULAR CELL 57:422-432(2015).
