ABCC3
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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -
Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. -
Synonyms
ABCC3;ATP-binding cassette, sub-family C (CFTR/MRP), member 3;canalicular multispecific organic anion transporter 2;cMOAT2;EST90757;MLP2;MOAT D;MRP3;ABC 31;ABC31;ABCC 3;ATP binding cassette sub family C (CFTR/MRP) member 3;ATP binding cassette sub family C;ATP binding cassette sub family C member 3;ATP-binding cassette sub-family C member 3;Canicular multispecific organic anion transporter;CMOAT 2;MLP 2;MOAT-D;MOATD;MRP 3;MRP3_HUMAN;Multi specific organic anion transporter D;Multi-specific organic anion transporter D;Multidrug resistance associated protein 3;Multidrug resistance associated protein;Multidrug resistance-associated protein 3;Multispecific organic anion tranporter D;OTTHUMP00000221667;OTTHUMP00000221668;OTTHUMP00000221670;multi-specific orga
Recombinant Proteins
- Human
- Mouse
- Rat
- E. coli
- Mammalian Cell
- E.coli
- HEK293
- N-His
- His
- His&T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HRAS-13934H | Recombinant Human HRAS protein, His-tagged | E. coli | Human | N-His | 1-170 aa | |
| ABCC3-1101M | Recombinant Mouse ABCC3 Protein | Mammalian Cell | Mouse | His |
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| ABCC3-405R | Recombinant Rat ABCC3 Protein | Mammalian Cell | Rat | His |
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| ABCC3-8118H | Recombinant Human ABCC3 protein, His & T7-tagged | E.coli | Human | His&T7 | Phe1291~Asp1523 |
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| ABCC3-9150HCL | Recombinant Human ABCC3 293 Cell Lysate | HEK293 | Human | Non |
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| ABCC3-0440H | Recombinant Human ABCC3 Protein (Phe1291-Asp1523), N-His-tagged | E.coli | Human | His | Phe1291-Asp1523 |
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| ABCC3-198M | Recombinant Mouse ABCC3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ABCC3-198M-B | Recombinant Mouse ABCC3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ABCC3-2466H | Recombinant Human ABCC3 protein(871-950 aa), C-His-tagged | E.coli | Human | His | 871-950 aa |
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| ABCC3-60R | Recombinant Rat ABCC3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ABCC3-60R-B | Recombinant Rat ABCC3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
ABCC3 involved in several pathways and played different roles in them. We selected most pathways ABCC3 participated on our site, such as ABC transporters,Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | SLC4A4,SLCO1A4,SLC9A3,SLC9A1,SLCO1A2,CYP7A1,ATP1A4,SCTR,GNAS,Car2 |
| ABC transporters | ABCB7,ABCB1,ABCB4,ABCD3A,ABCB11,ABCA13,ABCC5,ABCD3,SUR2A,ABCG3 |
Protein Function
ABCC3 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances,organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC3 itself. We selected most functions ABCC3 had, and list some proteins which have the same functions with ABCC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase activity, coupled to transmembrane movement of substances | ABCC1,ABCD4,ABCA5,ABCD3A,ABCG5,ABCA1,ABCC8,ABCG8,ABCC12,ABCC6 |
| organic anion transmembrane transporter activity | ABCC5,SLC17A3,MFSD10,SLCO1B2,SLCO1B3,SLCO1D1,SLC22A20,ABCC11,SLC22A6,SLC22A23 |
| ATP binding | MAP2K7,ATP11C,Atp8a2,UBE2I,MYH7B,ACSM3,NEK5,ANKK1,DCLK1A,RENBP |
Interacting Protein
ABCC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC3.
MLH1;ubiF;q81sm8_bacan;q8czu9_yerpe;tadA
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References
- Cheng, Y; Xu, J; et al. Circulating autoantibody to ABCC3 may be a potential biomarker for esophageal squamous cell carcinoma. CLINICAL & TRANSLATIONAL ONCOLOGY 15:398-402(2013).
- Liu, LL; Liu, NA; et al. Are circulating autoantibodies to ABCC3 transporter a potential biomarker for lung cancer?. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 138:1737-1742(2012).
