ABCB8
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Official Full Name
ATP-binding cassette, sub-family B (MDR/TAP), member 8 -
Overview
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.ABC proteins transport various molecules across extra- and intra-cellular membranes.ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).This protein is a member of the MDR/TAP subfamily.Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation.The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol.This protein may also play a role in the transport of phospholipids into mitochondrial membranes. -
Synonyms
ABCB8;ATP-binding cassette, sub-family B (MDR/TAP), member 8;ATP-binding cassette sub-family B member 8, mitochondrial;EST328128;M ABC1;MABC1;mitochondrial ABC protein;mitochondrial ATP-binding cassette 1;M-ABC1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Pongo Abelii
- Mus musculus
- E. coli
- Mammalian Cell
- E.coli
- HEK293
- In vitro E. coli expression system
- E.coli expression system
- N-GST
- His
- His&T7
- Non
- His&Fc&Avi
- His&SUMO
Involved Pathway
ABCB8 involved in several pathways and played different roles in them. We selected most pathways ABCB8 participated on our site, such as ABC transporters,ABC-family proteins mediated transport,Mitochondrial ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCC11,ABCC10,ABCA3,ABCD1,ABCC1,ABCC4,TAP2,ABCA1,ABCG3,ABCG2 |
| ABC-family proteins mediated transport | EIF2S3,ABCA4A,CFTR,ABCA7,KCNJ11,ABCF1,ABCC2,ABCG4B,ABCE1,ABCA8 |
| Transmembrane transport of small molecules | TRPC5A,SLC30A3,SLC6A6,SLC7A3A,SLC22A16,MAGT1,ATP13A,SLC39A2,AQP10B,SLC22A7A |
Protein Function
ABCB8 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances,transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCB8 itself. We selected most functions ABCB8 had, and list some proteins which have the same functions with ABCB8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | HSP70L,VRK1,AKT2L,BMPR1AB,ACSM2B,TTLL9,SGK2B,TNIK,TOR1L1,TOR1 |
| ATPase activity, coupled to transmembrane movement of substances | ABCA5,ABCA4,ABCB1,ABCD3B,ABCG8,ABCC9,SFRP5,ABCG3,ABCG2D,ABCC1 |
| transporter activity | ATP6V0B,FABP7B,HIATL1,SLC2A15B,PTGDSB,LCN2,SLCO1F3,NUP88,FABP1A,MIPA |
Interacting Protein
ABCB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCB8.
SAT1;NOA1
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References
- Lin, KM; Chiu, YF; et al. ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment. PHARMACOGENETICS AND GENOMICS 21:163-170(2011).
