ABCA7
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Official Full Name
ATP-binding cassette, sub-family A (ABC1), member 7 -
Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is widely expressed with highest detection in spleen and hematopoietic tissues. The function of this protein has not yet been determined; however, a related human protein is thought to play a role in lipid homeostasis in cells of the immune system. -
Synonyms
ABCA7;ATP-binding cassette, sub-family A (ABC1), member 7;ATP-binding cassette sub-family A member 7;ABC transporter ABCA7;ABC transporter member 7;ABCA SSN;ABCX;ATP binding cassette sub family A (ABC1) member 7;ATP binding cassette sub family A member 7;ATP binding Cassette Transporter A7;FLJ40025;Macrophage ABC transporter;OTTMUSP00000043312;Abc51
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- His
- His&GST
- His&Fc&Avi
- GST
Involved Pathway
ABCA7 involved in several pathways and played different roles in them. We selected most pathways ABCA7 participated on our site, such as ABC transporters,ABC transporters in lipid homeostasis,ABC-family proteins mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC-family proteins mediated transport | ABCF1,ABCE1,ABCG4B,ABCA4A,KCNJ11,EIF2S1,EIF2S1A,APOA1B,ABCA8,ABCD3B |
| ABC transporters | ABCC12,ABCC5,ABCB7,ABCC6,ABCA9,ABCG2A,ABCD4,ABCA3,ABCA6,ABCC8 |
| ABC transporters in lipid homeostasis | APOA1B,ABCG4B,ABCD3B |
| Transmembrane transport of small molecules | CLCN6,RHCG2A,ATP1A1A.4,WNK1,SLC6A9,CTNS,SCNN1D,SLC26A3.2,SLC24A6,SLC13A1 |
Protein Function
ABCA7 has several biochemical functions, for example, ATP binding,contributes_to ATPase activity,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA7 itself. We selected most functions ABCA7 had, and list some proteins which have the same functions with ABCA7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cholesterol transporter activity | ABCA13,APOA4B.2,ABCG4B,APOB,ABCG1,APOA4B.1,ABCA4A,APOEB,ABCA4,APOA4 |
| transporter activity | ABCA3,CRABP2A,SLC2A1A,SYPA,CPNE3,RBP7,SLC22A13,ATP6V0E1,AQP1A.1,SLCO4C1 |
| contributes_to ATPase activity | RUVBL2,ABCG8,MSH2,ATP1A2,ATP5D,PPP2R4,ATP5O,ATP1B1,ATP5F1,ATP6V1H |
| phospholipid transporter activity | ABCA1B,ATP8B5,OSBPL8,ABCG1,APOA1,CETP,ABCA13,MFSD2AB,ABCA1,GLTPD1 |
| ATPase activity, coupled to transmembrane movement of substances | ABCA3,ABCC3,ABCB6A,ABCA13,ABCC6,Abcb1b,ABCA5,ABCD2,ABCA6,ABCC5 |
| ATP binding | CCT3,TTLL11,PFKM,HSP70,GRK4,DCLK2,YME1L1,MAP3K12,MAGI1,ERBB2 |
| apolipoprotein A-I receptor activity | ABCA1 |
Interacting Protein
ABCA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA7.
Resources
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References
- Morales, CR; Ni, XY; et al. ABCA17 mediates sterol efflux from mouse spermatozoa plasma membranes. HISTOLOGY AND HISTOPATHOLOGY 27:317-328(2012).
- Morales, CR; Marat, AL; et al. ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 376:472-477(2008).
