ABCA12
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Official Full Name
ATP-binding cassette, sub-family A (ABC1), member 12 -
Overview
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. -
Synonyms
ABCA12;ATP-binding cassette, sub-family A (ABC1), member 12;ichthyosis congenita II, lamellar ichthyosis B , ICR2B;ATP-binding cassette sub-family A member 12;DKFZP434G232;LI2;ATP-binding cassette transporter 12;ICR2B;FLJ41584
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ABCA12-7853H | Recombinant Human ABCA12 protein, His & T7-tagged | E.coli | Human | His&T7 | Val1346~Thr1577 |
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Involved Pathway
ABCA12 involved in several pathways and played different roles in them. We selected most pathways ABCA12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ABCA12 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA12 itself. We selected most functions ABCA12 had, and list some proteins which have the same functions with ABCA12. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
ABCA12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA12.
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References
- Haller, JF; Cavallaro, P; et al. Endogenous beta-glucocerebrosidase activity in Abca12(-/-) epidermis elevates ceramide levels after topical lipid application but does not restore barrier function. JOURNAL OF LIPID RESEARCH 55:493-503(2014).
- Sakai, K; Akiyama, M; et al. Localization of ABCA12 from Golgi apparatus to lamellar granules in human upper epidermal keratinocytes. EXPERIMENTAL DERMATOLOGY 16:920-926(2007).
- Stahlman, MT; Besnard, V; et al. Expression of ABCA3 in developing lung and other tissues. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 55:71-83(2007).
