AATK
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Official Full Name
apoptosis-associated tyrosine kinase -
Overview
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
AATK;apoptosis-associated tyrosine kinase;serine/threonine-protein kinase LMTK1;AATYK;AATYK1;KIAA0641;lemur tyrosine kinase 1;LMR1;LMTK1;p35-binding protein;CDK5-binding protein;brain apoptosis-associated tyrosine kinase;p35BP
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AATK-029H | Recombinant Human AATK Protein, GST-tagged | Wheat Germ | Human | GST |
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| AATK-3037H | Recombinant house mouse AATK, GST-tagged | Sf9 Cells | Mouse | GST | 5706 |
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| AATK-645H | Recombinant Human AATK Protein, His-tagged | E.coli | Human | His | Leu1216~Ala1374 |
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| Aatk-646M | Recombinant Mouse Aatk Protein, His-tagged | E.coli | Mouse | His | Tyr137~Gln386 |
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| AATK-6993M | Recombinant Mouse AATK, GST-tagged | Sf9 Cells | Mouse | GST | 8-411 aa |
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Involved Pathway
AATK involved in several pathways and played different roles in them. We selected most pathways AATK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AATK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
AATK has several biochemical functions, for example, ATP binding,kinase activity,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AATK itself. We selected most functions AATK had, and list some proteins which have the same functions with AATK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase activity | GSG2,LRRK2,TGFBR1,FASTKD5,CDKL5,ACVR1BA,CSNK1DA,CASKB,NLK2,PDPK1A |
| transferase activity | NMT1A,CHST3B,UBE2D2A,BMPR1BA,ST6GAL2A,Sult3a1,HRASLS,TAB3,MAPK12A,PTK2BB |
| protein tyrosine kinase activity | DSTYK,KITA,ABL1,FER,CLK4,LYN,MAP2K5,ABL2,FGFR3,KDRL |
| protein binding | CHAC1,AKT3,ICK,UQCC2,GPM6A,ACAA1,DCLRE1B,MAPK13,DHH,C6orf130 |
| ATP binding | ATP6V1AA,KIF7,KCNJ10,PFKMB,MAPK4,RLN1,PDK4,RIPK4,SMC6,ATP8B1 |
| nucleotide binding | POLA1,RHOT1A,PSMC1A,ARF6B,HNRNPA0B,PRKACBB,U2AF1,PPARGC1A,NXF3,TUBA8L2 |
| kinase activity | PHKG1A,WNK2,SGMS2,MAPK14B,RAF1A,PIP5K1BA,CAMKK1A,PRKACAA,SRC,NME2B.2 |
| protein serine/threonine kinase activity | NLK2,ERN1,ALPK1,MAPK8A,PINK1,MAPK12,STK36,STK32B,MAP2K2,MAPK13 |
Interacting Protein
AATK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AATK here. Most of them are supplied by our site. Hope this information will be useful for your research of AATK.
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References
- Ling, YH; Lin, RP; et al. Erlotinib induces mitochondrial-mediated apoptosis in human H3255 non-small-cell lung cancer cells with epidermal growth factor receptor(L858R) mutation through mitochondrial oxidative phosphorylation-dependent activation of BAX and BAK. MOLECULAR PHARMACOLOGY 74:793-806(2008).
- Nishioka, C; Ikezoe, T; et al. Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo. BLOOD 111:5086-5092(2008).
