AANAT
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Official Full Name
aralkylamine N-acetyltransferase -
Overview
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants. -
Synonyms
AANAT;aralkylamine N-acetyltransferase;arylalkylamine N acetyltransferase;serotonin N-acetyltransferase;serotonin N acetyltransferase;SNAT;serotonin acetylase;arylalkylamine N-acetyltransferase;DSPS
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Chicken
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- His
- GST
- His&T7
- His&Fc&Avi
- His&GST
Involved Pathway
AANAT involved in several pathways and played different roles in them. We selected most pathways AANAT participated on our site, such as Tryptophan metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AANAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CRLS1,REV3L,POLR2J2,SAT1A.2,DHCR7,NAGS,ITPK1A,ALOX8,CAD,DNMT3AB |
| Tryptophan metabolism | AANAT2,RNF25,MAOB,GCDHB,HADH,ALDH1B1,AOX4,CYP1A,INMT,TPH1B |
Protein Function
AANAT has several biochemical functions, for example, 14-3-3 protein binding,N-acetyltransferase activity,aralkylamine N-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AANAT itself. We selected most functions AANAT had, and list some proteins which have the same functions with AANAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transferase activity, transferring acyl groups | ACNAT2,Nat3,LYCAT,ZDHHC18,CML5,AANAT2,ZDHHC23B,ZDHHC16,CML2,DGAT2L6 |
| N-acetyltransferase activity | SAT1A.2,LPCAT3,MBOAT1,MBOAT4,AANAT2,NAT15,NAT6,SAT1B,NAA10,Acnat1 |
| transferase activity | PNP5A,GGT1A,LIPT2,ZDHHC21,SULT3ST3,COMTB,ELOVL4A,B3GNT2B,SMYD2A,CAMK1DA |
| arylamine N-acetyltransferase activity | PNAT3,NAT,NAT2,PNAT10,Nat3 |
| aralkylamine N-acetyltransferase activity | AANAT1,AANAT2 |
| 14-3-3 protein binding | KCNH1,PRKCZ,IRS2,HDAC7,AKT1,HDAC7A,RPTOR,PPP1R12A,DDIT4,KIF13B |
Interacting Protein
AANAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AANAT here. Most of them are supplied by our site. Hope this information will be useful for your research of AANAT.
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