AADAT
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Official Full Name
aminoadipate aminotransferase -
Overview
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist. -
Synonyms
AADAT;aminoadipate aminotransferase;kynurenine/alpha-aminoadipate aminotransferase, mitochondrial;KAT2;KATII;kynurenine aminotransferase II;L kynurenine/alpha aminoadipate aminotransferase;KAT/AadAT;2-aminoadipate transaminase;2-aminoadipate amin
Recombinant Proteins
- Mouse
- Human
- Rat
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
- His&SUMO
- Flag
Involved Pathway
AADAT involved in several pathways and played different roles in them. We selected most pathways AADAT participated on our site, such as Lysine biosynthesis,Lysine degradation,Tryptophan metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AADAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| -Oxocarboxylic acid metabolism | GOT2,ACY1,IDH2,BCAT1,GOT2A,IDH3B,IDH3A,GOT2B,GPT2,ACO1 |
| Lysine biosynthesis | ALDH7A1 |
| Metabolic pathways | OTC,CYP3A5,UQCR11,PCK2,NAMPTB,SAT1A.2,ACSL5,ZNF408,PPAT,AGPAT4 |
| Biosynthesis of amino acids | IDH3B,GLULC,ALDOCA,RPIA,MAT1A,PRPS2,PKM,PKMB,PKMA,PHGDH |
| Lysine degradation | WHSC1L1,SETDB1,BBOX1,HADHAB,PIPOX,PLOD3,ACAT1,PLOD2,SUV420H1,ALDH9A1 |
| Tryptophan metabolism | AOX1,MAOB,AOX3,IL4I1,RNF25,OGDHL,ACAT1,AOX4,AOX2P,KYNU |
Protein Function
AADAT has several biochemical functions, for example, 2-aminoadipate transaminase activity,kynurenine-oxoglutarate transaminase activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AADAT itself. We selected most functions AADAT had, and list some proteins which have the same functions with AADAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kynurenine-oxoglutarate transaminase activity | GOT2,CCBL2,CCBL1 |
| protein homodimerization activity | NLGN4X,GABPB2,MZF1,HPGD,CD2,NKX2-5,SETMAR,PRMT2,CADM1A,BCL11A |
| pyridoxal phosphate binding | PHYKPL,SHMT1,PYGMB,GPT2L,CBSB,SPTLC2A,PDXDC2P,TAT,PYGM,GCAT |
Interacting Protein
AADAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AADAT here. Most of them are supplied by our site. Hope this information will be useful for your research of AADAT.
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References
- Guidetti, P; Amori, L; et al. Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain. JOURNAL OF NEUROCHEMISTRY 102:103-111(2007).
- BARAN, H; OKUNO, E; et al. PURIFICATION AND CHARACTERIZATION OF KYNURENINE AMINOTRANSFERASE-I FROM HUMAN BRAIN. JOURNAL OF NEUROCHEMISTRY 62:730-738(1994).
- MAWAL, MR; DESHMUKH, DR; et al. ALPHA-AMINOADIPATE AMINOTRANSFERASE AND KYNURENINE AMINOTRANSFERASE ACTIVITIES FROM RAT-KIDNEY - EVIDENCE FOR SEPARATE IDENTITY. JOURNAL OF BIOLOGICAL CHEMISTRY 266:2573-2575(1991).
