A4GALT
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Official Full Name
Alpha 1,4-Galactosyltransferase -
Overview
The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. -
Synonyms
A4GALT;alpha 1,4-galactosyltransferase;P1;PK;Gb3S;P(k);A14GALT;A4GALT1;lactosylceramide 4-alpha-galactosyltransferase;GB3 synthase;alpha4Gal-T1;CD77 synthase;P1/Pk synthase;P(k) antigen synthase;P blood group (P one antigen);globotriaosylceramide synthase;alpha-1,4-N-acetylglucosaminyltransferase;UDP-galactose: beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase;NP_059132.1;EC 2.4.1.228
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| A4GALT-9186H | Recombinant Human A4GALT, GST-tagged | E.coli | Human | GST | 41-353a.a. | |
| A4GALT-005H | Recombinant Human A4GALT Protein, GST-tagged | Wheat Germ | Human | GST |
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| A4GALT-379R | Recombinant Rat A4GALT Protein | Mammalian Cell | Rat | His |
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| A4GALT-5510C | Recombinant Chicken A4GALT | Mammalian Cell | Chicken | His |
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| A4GALT-9187H | Recombinant Human A4GALT protein, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 353 a.a. |
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| A4GALT-9163HCL | Recombinant Human A4GALT 293 Cell Lysate | HEK293 | Human | Non |
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| A4GALT-34R | Recombinant Rat A4GALT Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| A4GALT-34R-B | Recombinant Rat A4GALT Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| A4GALT-483H | Recombinant Human A4GALT Protein, His-tagged | E.coli | Human | His | Gly44~Leu353 |
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| A4galt-484M | Recombinant Mouse A4galt Protein, His-tagged | E.coli | Mouse | His | Thr94~Ile270 |
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| A4galt-485R | Recombinant Rat A4galt Protein, His-tagged | E.coli | Rat | His | Cys142~Thr357 |
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| A4GALT-574HF | Recombinant Full Length Human A4GALT Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 353 amino acids |
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Involved Pathway
A4GALT involved in several pathways and played different roles in them. We selected most pathways A4GALT participated on our site, such as Glycosphingolipid biosynthesis - globo series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with A4GALT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | POLR2E,PLB1,ACSS2,SCP2,MTHFD2,B3GNT2B,ST6GAL2,EXT1A,H6PD,ALDH5A1 |
| Glycosphingolipid biosynthesis - globo series | B3GALNT1,HEXA,FUT9,NAGA,FUT2,FUT1,FUT9A,ST3GAL1,B3GALT5,GBGT1 |
Protein Function
A4GALT has several biochemical functions, for example, galactosyltransferase activity,lactosylceramide 4-alpha-galactosyltransferase activity,toxic substance binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A4GALT itself. We selected most functions A4GALT had, and list some proteins which have the same functions with A4GALT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| galactosyltransferase activity | B4GALT4,B3GNT7,B4GALT3,B3GNT9-PS,B3GNT8,DPY19L1,C1GALT1,B3GALT6,B3GNT4,B3GNT5 |
| toxic substance binding | GUCY2C,ASS1,AZU1,PHAX,H2-AB1,NEFH,Alb,EPHX2,DSG1,CHRNA7 |
Interacting Protein
A4GALT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A4GALT here. Most of them are supplied by our site. Hope this information will be useful for your research of A4GALT.
Dlg4;rab40c
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References
- Lai, YJ; Wu, WY; et al. A systematic study of single-nucleotide polymorphisms in the A4GALT gene suggests a molecular genetic basis for the P-1/P-2 blood groups. TRANSFUSION 54:3222-3231(2014).
- Westman, JS; Hellberg, A; et al. Large deletions involving the regulatory upstream regions of A4GALT give rise to principally novel P1PK-null alleles. TRANSFUSION 54:1831-1835(2014).
