ZEB1
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Official Full Name
zinc finger E-box binding homeobox 1 -
Overview
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
ZEB1;zinc finger E-box binding homeobox 1;posterior polymorphous corneal dystrophy 3 , PPCD3, TCF8, transcription factor 8 (represses interleukin 2 expression);zinc finger E-box-binding homeobox 1;AREB6;BZP;NIL 2 A;ZEB;Zfhep;Zfhx1a;AREB 6;DELTA EF1;MGC133261;Negative regulator of IL 2;Negative regulator of IL2;NIL 2 A zinc finger protein;NIL 2A;NIL-2-A zinc finger protein;NIL2A;Represses interleukin 2 expression;TCF 8;TCF-8;TCF8;Transcription factor 8 (represses interleukin 2 expression);Transcription factor 8;ZEB 1;ZEB1_HUMAN;ZFHX 1A;Zinc finger E box binding homeobox 1;Zinc finger homeodomain enhancer binding protein;OTTHUMP00000019404;OTTHUMP00000019405;OTTHUMP00000019406;delta-crystallin enhancer binding factor 1;posterior polymorphous corneal dystrophy 3;zinc finger homeodomain enhancer-binding protein;FECD6;PPCD3;DELTAEF1
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ZEB1-3796H | Recombinant Human ZEB1, GST-tagged | E.coli | Human | GST | 391-740aa | |
| ZEB1-18798M | Recombinant Mouse ZEB1 Protein | Mammalian Cell | Mouse | His |
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| ZEB1-22H | Recombinant Human ZEB1 Protein, GST-tagged | Wheat Germ | Human | GST | 801 a.a. - 900 a.a. |
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| ZEB1-6688C | Recombinant Chicken ZEB1 | Mammalian Cell | Chicken | His |
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| ZEB1-190HCL | Recombinant Human ZEB1 293 Cell Lysate | HEK293 | Human | Non |
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| ZEB1-10324M | Recombinant Mouse ZEB1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ZEB1-10324M-B | Recombinant Mouse ZEB1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ZEB1-604H | Recombinant Human ZEB1 Protein, His-tagged | E.coli | Human | His | Tyr904-Ala1124 |
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Involved Pathway
ZEB1 involved in several pathways and played different roles in them. We selected most pathways ZEB1 participated on our site, such as Transcriptional misregulation in cancer,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZEB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | SOS1,HNRNPK,PRKCB,ZEB2,NOTCH3,MARCKS,CDC25A,DNMT1,PDGFRA,ERBB3 |
| Transcriptional misregulation in cancer | RELA,HIST3H3,MMP9,Itgam&Itgb2,SMAD1,PLAU,ZBTB16,NCOR1,SSX2,TRP53 |
Protein Function
ZEB1 has several biochemical functions, for example, E-box binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZEB1 itself. We selected most functions ZEB1 had, and list some proteins which have the same functions with ZEB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NCBP2,FKBP4,RRM2,TNFRSF1B,FAM54B,WDR4,ASB13,DES,MATN1,PRKAB1 |
| transcription corepressor activity | KCNIP3,E2F8,ERF,RLIM,ZHX2,SP100,DNMT3B,CTCF,RBFOX2,ZFPM2 |
| chromatin binding | PHF8,ANKRD2,SALL1,HDAC2,PKN1,JDP2,NKX2-5,HMGB1,NR5A1,RAG2 |
| zinc ion binding | DDX41,ARIH1,ZCCHC16,SRSF7A,TOPORS,DTX1,SEC24D,PDLIM3B,RNF125,RNF7 |
| transcription factor activity, sequence-specific DNA binding | ZNF577,CSRNP2,AHCTF1,SOLH,ZNF606,HOXA13,FOXJ1A,FOXP2,ELF2A,HOXC8 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | E4F1,FOXD3,HOXD9,CDX2,KLF6A,ARID5B,FOXO3,ZBTB12.2,KLF12,ETV7 |
| transcription coactivator activity | HTATIP2,MTDH,TFAP2B,SUPT7L,CEBPA,SETD3,MED17,ACTL6A,GMEB1,TAF12 |
| E-box binding | MYC,TFAP4,NEUROD1,TWIST1,ATOH8,TCF4,BHLHE40,PER1,ARNTL,NEUROG2 |
| transcription factor binding | TLE1,SUMO1,EP300,NFKBIA,HAND1,PBX2,PDCD11,HDAC7,HDAC11,ZFPM1 |
Interacting Protein
ZEB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZEB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZEB1.
CDK6;CTBP1;yscH;ifnl1_human_gene;SYNCRIP
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References
- Gamba, CO; Campos, LC; et al. ZEB2 and ZEB1 expression in a spontaneous canine model of invasive micropapillary carcinoma of the mammary gland. RESEARCH IN VETERINARY SCIENCE 97:554-559(2014).
- Lee, JH; Nam, H; et al. Upregulation of GM-CSF by TGF-beta 1 in epithelial mesenchymal transition of human HERS/ERM cells. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 50:399-405(2014).
