XPO5
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Official Full Name
exportin 5 -
Overview
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. -
Synonyms
XPO5;exportin 5;exportin-5;KIAA1291;Exp 5;Exp5;Exportin5;FLJ14239;FLJ32057;FLJ45606;OTTHUMP00000016472;Ran binding protein 21;Ran-binding protein 21;Ranbp 21;Ranbp21;Xpo 5;XPO5_HUMAN
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
XPO5 involved in several pathways and played different roles in them. We selected most pathways XPO5 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPO5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | TGS1,NUP88,NUP62L,SUMO2,EIF2B1,EIF3EB,THOC1,PNN,EIF3D,RPP30 |
Protein Function
XPO5 has several biochemical functions, for example, RNA binding,Ran GTPase binding,mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XPO5 itself. We selected most functions XPO5 had, and list some proteins which have the same functions with XPO5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | TIMM50,PUSL1,NANOS3,RBMS1,C14orf166,DDX19B,BARD1,MCTS2,RPS7,RBBP7 |
| Ran GTPase binding | NXT1,RANBP2,IPO9,XPO6,DPY19L2,RANBP1,KPNB1,IPO5,IPO13,XPO1 |
| tRNA binding | SSB,EARS2,TRMT11,SEPSECS,TYW5,XPOT,AARS,KARS,NSUN2,RARS |
| protein binding | GSTO2,AKAP17A,DUSP21,PCK2,HNRPLL,ELP4,MPP1,ARPC5,UBE2E2,UBE2B |
| protein transporter activity | COX18,VPS26A,RAP1A,KPNA3,CALCR,CALCRL,VPS26BL,SEC62,TIMM9,CCT6B |
| contributes_to pre-miRNA binding | DICER1,TARBP2,RAN |
| pre-miRNA binding | DICER1,TARBP2 |
| poly(A) RNA binding | RTCD1,Api5,DHX30,GTPBP1,CIRBP,DHX33,EWSR1,UBAP2,BTF3,DEK |
| mRNA binding | RC3H2,DHFR,EIF4A3,RPS26,MRPL13,C1QBP,CPSF5,SSB,ELAVL1,CSTF3 |
Interacting Protein
XPO5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPO5 here. Most of them are supplied by our site. Hope this information will be useful for your research of XPO5.
pre-let-7a-1;MYC;vpu;Dlg4;PTP4A3;TNFRSF1B;MAGEA6;ARF6;RAN;CCNA1;FADD;SERINC3;IKBKE;TSC22D1;NEK6
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References
- Khacho, M; Mekhail, K; et al. eEF1A Is a Novel Component of the Mammalian Nuclear Protein Export Machinery. MOLECULAR BIOLOGY OF THE CELL 19:5296-5308(2008).
- Kurihara, Y; Kawamura, Y; et al. Maintenance of genomic methylation patterns during preimplantation development require's the somatic form of DNA methyltransferase 1. DEVELOPMENTAL BIOLOGY 313:335-346(2008).
