XPO1

  • Official Full Name

    exportin 1

  • Overview

    The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jul 2008]

  • Synonyms

    XPO1;exportin 1;emb;CRM1;exp1;exportin-1;CRM1, yeast, homolog;exportin 1 (CRM1 homolog, yeast);chromosome region maintenance 1 homolog;chromosome region maintenance 1 protein homolog;exportin-1 (required for chromosome region maintenance)

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • Rat
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
XPO1-3753H Recombinant Human XPO1, GST-tagged E.coli Human GST N-term-302aa
XPO1-3796H Recombinant Human XPO1 protein, His-tagged E.coli Human His 301-540 aa
XPO1-2087C Recombinant Chicken XPO1 Mammalian Cell Chicken His
XPO1-3754H Recombinant Human XPO1, GST-tagged Wheat Germ Human GST
XPO1-5230R Recombinant Rhesus monkey XPO1 Protein, His-tagged Mammalian Cell Rhesus macaque His
XPO1-5491C Recombinant Chicken XPO1 Mammalian Cell Chicken His
XPO1-6619R Recombinant Rat XPO1 Protein Mammalian Cell Rat His
XPO1-259HCL Recombinant Human XPO1 293 Cell Lysate HEK293 Human Non
XPO1-460H Recombinant Human XPO1 Protein, His-tagged E.coli Human His Thr917~Asp1071
XPO1-5043R Recombinant Rhesus Macaque XPO1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
XPO1-5043R-B Recombinant Rhesus Macaque XPO1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
XPO1-5164H Recombinant Human XPO1 Protein (Thr917-Asp1071), His tagged E.coli Human His Thr917-Asp1071
XPO1-551HF Recombinant Full Length Human XPO1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 1071 amino acids
XPO1-6275R Recombinant Rat XPO1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
XPO1-6275R-B Recombinant Rat XPO1 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    XPO1 involved in several pathways and played different roles in them. We selected most pathways XPO1 participated on our site, such as Ribosome biogenesis in eukaryotes,RNA transport,Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    HTLV-I infection PTTG2,WNT1,SLC25A5,IL6,XBP1,ITGB2L,ANAPC11,SMAD2,WNT2,RELA
    Ribosome biogenesis in eukaryotes NHP2L1,cka1,NOB1,NHP2L1A,LSG1,cka2,TCOF1,NOP56,NHP2L1B,RNASEN
    Epstein-Barr virus infection HDAC4,TRAF1,FGR,CD58,EIF2AK2,PSMD6,POLR3C,ITGAL,HSPA1B,CCNA1
    Influenza A MAP2K2,TMPRSS2,HLA-DQA1,SLC25A6,MAPK1,CPSF4,MAVS,FASLG,NLRP3,CYCS
    RNA transport CASC3,RPP14,EIF3H,RPP40,MAGOH2,CYFIP2,THOC4,EIF4EBP3,NXF1,RANBP2

    Protein Function

    XPO1 has several biochemical functions, for example, RNA binding,Ran GTPase binding,nucleocytoplasmic transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XPO1 itself. We selected most functions XPO1 had, and list some proteins which have the same functions with XPO1. You can find most of the proteins on our site.

    Function Related Protein
    Ran GTPase binding KPNB1,TNPO2,RANBP1,CSE1L,IPO13,RANGRF,RANBP2,IPO8,NUTF2,NUP153
    protein transporter activity RANBP6,SEC62,MLC1,AP1B1,AP2A1,RAMP1,AP2B1,DSCR3,COX18,XPO6
    transporter activity SLC2A8,ABCC1,SLCO1A5,SLCO1F4,FLR,FABP5,FLVCR1,ABCG2,MIPB,RBP4L
    nucleocytoplasmic transporter activity NUP153,NUP107,NUP54,UPF3A,TPR,NUP214,NUPL1,NUP160,RBM22,NUP133
    RNA binding KIAA0907,EXOSC6,SRSF10,MOV10B.2,FMR1,EMG1,CWC22,SNRPE,DPPA5,RPS3
    protein binding DNMT1,SH3PXD2A,MED6,ESRP1,SZT2,LBX1,HDAC5,UBE3A,ZBTB26,KLB
    protein domain specific binding RXRA,LAMP1,ABCC2,KCNN2,HPCAL4,HIST1H4L,ACSL3,NCK1,AKAP1,STX1B

    Interacting Protein

    XPO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XPO1.

    YWHAZ;VCAM1;BIRC5;vpu;TGS1;HAX1;ERBB2;TP53;RCC1

    Resources

    References

    Reviews

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    Reviews
    06/05/2024

    Your product worked well and that project finished a couple of months ago.

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