XBP1
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Official Full Name
X-box binding protein 1 -
Overview
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008] -
Synonyms
XBP1;X-box binding protein 1;XBP2;TREB5;XBP-1;X-box-binding protein 1;tax-responsive element-binding protein 5
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- His&GST
- His
- T7
- Non
- His&Fc&Avi
Involved Pathway
XBP1 involved in several pathways and played different roles in them. We selected most pathways XBP1 participated on our site, such as Protein processing in endoplasmic reticulum,Non-alcoholic fatty liver disease (NAFLD),HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with XBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | RRBP1,ATF6,SEC31B,DNAJC3A,BAK1,UBE2D1,RPN1,GSBP9,RAD23B,SEC24D |
| Non-alcoholic fatty liver disease (NAFLD) | PKLR,NDUFB10,SDHC,MAPK9,TRAF2,LEP,MLXIPL,NDUFS2,TNF,UQCRC1 |
| HTLV-I infection | WNT1,TCF3,MAP3K14,PDGFRA,CRTC2,H2-AA,XPO1,ANAPC2,BUB3,NFATC2 |
Protein Function
XBP1 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XBP1 itself. We selected most functions XBP1 had, and list some proteins which have the same functions with XBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enhancer sequence-specific DNA binding | ATF2,KLF7B,MYT1,TBX19,GATA3,KLF6A,TFAP2B,YY1,GATA5,TWIST1B |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXC1B,PAX6B,ATF5A,MKX,SIM2,PLAG1,ELF3,FOXM1,NFIB,TAL1 |
| histone deacetylase binding | HEY2,PKN1,NUDT21,HDAC10,MAGEA2B,NCOR2,NR2C1,CEBPB,TRAF6,BRMS1LA |
| phosphatidylinositol 3-kinase regulatory subunit binding | FAM83B,DNM2,PIK3R1,FAM83A,PIK3AP1,PTPN13 |
| protein homodimerization activity | HRSP12,S100A11,SYNE1,TCF3A,SLC9A7,AOC3,MITD1,DNTTIP1,KCNH2,STOM |
| core promoter binding | MYOG,DHX36,NPAS2,NKX3-1,RELB,E2F7,HDAC6,GTF2B,AGO2,GADD45A |
| RNA polymerase II regulatory region sequence-specific DNA binding | BARHL1B,RUNX3,PCGF6,ATF4B1,MYOD1,GATA4,TRP53,HES6,LEF1,ZNF812 |
| protein heterodimerization activity | MCL1A,MAFA,VEGFA,CHRNA5,HIST2H2L,Itgam&Itgb2,GCLM,P4HB,SMAD1,KCNN1 |
| DNA binding | HIST3H3,SIX6B,RPAP1,NR2F5,HOXC13A,ZNF124,HOXB2,ZBTB25,FAM170A,SURF6 |
Interacting Protein
XBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XBP1.
ATF6;CREBZF;CANX
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References
- Kitabatake, M; Soma, M; et al. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. JOURNAL OF IMMUNOLOGY 194:1480-1488(2015).
- van't Wout, EFA; van Schadewijk, A; et al. Function of monocytes and monocyte-derived macrophages in alpha(1)-antitrypsin deficiency. EUROPEAN RESPIRATORY JOURNAL 45:365-376(2015).
