WWP1

  • Official Full Name

    WW domain containing E3 ubiquitin protein ligase 1

  • Overview

    WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

  • Synonyms

    WWP1;WW domain containing E3 ubiquitin protein ligase 1;AIP5;Tiul1;hSDRP1;NEDD4-like E3 ubiquitin-protein ligase WWP1;WW domain-containing protein 1;atrophin-1 interacting protein 5;atrophin-1-interacting protein 5;TGIF-interacting ubiquitin ligase 1;Nedd-4-like ubiquitin-protein ligase

Recombinant Proteins

  • Chicken
  • Human
  • Rhesus macaque
  • Mammalian Cell
  • Insect Cell
  • Sf9 Insect Cell
  • HEK293
  • His
  • Flag
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
WWP1-1926C Recombinant Chicken WWP1 Mammalian Cell Chicken His
WWP1-31531TH Recombinant Human WWP1, FLAG-tagged Insect Cell Human Flag 921 amino acids
WWP1-477H Recombinant Human WWP1, GST-tagged Sf9 Insect Cell Human Flag 2-end a.a.
WWP1-5224R Recombinant Rhesus monkey WWP1 Protein, His-tagged Mammalian Cell Rhesus macaque His
WWP1-75H Recombinant Human WWP1, GST-tagged Sf9 Insect Cell Human GST
WWP1-273HCL Recombinant Human WWP1 293 Cell Lysate HEK293 Human Non
WWP1-5037R Recombinant Rhesus Macaque WWP1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
WWP1-5037R-B Recombinant Rhesus Macaque WWP1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    WWP1 involved in several pathways and played different roles in them. We selected most pathways WWP1 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with WWP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis FOLR1,EHD1A,ARAP2,GRK1B,ARR3B,MVB12BB,VPS24,CXCR4A,CAPZA1B,SMURF2
    ErbB4 signaling events WWOX,CBFA2T3,YAP1
    Ion channel transport TRPA1B,TRPV3,TRPC4A,PDZD11,CLCN4,GABRR2A,ATP2B1B,MCOLN2,ANO10A,ANO8
    Immune System CTSB,ARIH1L,PPIAL4A,VPRBP,UBE2U,IFIT8,ASB18,ICAM4,LRRC41,TRIM9
    presentation RNF14,RNF123,DTX3L,MKRN1,UBE2V2,ERAP2,STUB1,UFL1,HECTD3,UBE2E3
    Adaptive Immune System KIF26A,CD200R2,ASB9,OSCAR,CYBA,CLEC2D,DNM2,DYNC1LI2,IGKC,CD200R4
    Antigen processing: Ubiquitination &amp SPSB1,TRIM63,HECTD3,MKRN1,TRIM50,UBE2L6,SPSB4,RNF4,ASB11,DZIP3
    Proteasome degradation IWS1,TPP2,SPSB1,PJA2,ASB9,KLHL20,ATG7,TRAF7,PJA1,LRSAM1
    Class I MHC mediated antigen processing &amp CTSL1,TRIM39,DTX3L,FBXO44,RNF220,RNF4,CYBA,SEC23A,UBE2L6,UBR1

    Protein Function

    WWP1 has several biochemical functions, for example, ligase activity,protein binding,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WWP1 itself. We selected most functions WWP1 had, and list some proteins which have the same functions with WWP1. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin-protein transferase activity DTX3L,RC3H2,FANCL,FBXO3,UBE2D3,BIRC7,NHLRC1,SMURF1,UBE3A,TRIM24
    ubiquitin protein ligase activity FANCF,RNF41,PPIL2,ANKIB1A,MGRN1,ZNRF1,TRIM6,UBE3C,BFAR,RNF6
    ligase activity RNF139,TRIM63,RNF14,SHRPRBCK1R,MUL1A,RNF126,MARCH1,CBLC,TTLL2,HERC5
    protein binding DOCK1,AAGAB,MTPAP,SPSB4,TRAF5,MPP6,HBB,BLZF1,FGB,SELE

    Interacting Protein

    WWP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WWP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WWP1.

    CPSF6;SMAD3;q8wu02_human;FBXL18;TRAF4;HSP90AB1;FBXL15;PHF20L1;WASL

    Resources

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