WRAP53
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Official Full Name
WD repeat containing, antisense to TP53 -
Overview
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5" untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5" UTR have been found for this gene. -
Synonyms
WRAP53;WD repeat containing, antisense to TP53;TCAB1;WDR79;FLJ10385;telomerase Cajal body protein 1;OTTHUMP00000166046;OTTHUMP00000166047;OTTHUMP00000233829;OTTHUMP00000233830;OTTHUMP00000233831;WD repeat domain 79;WD40 protein Wrap53;WD repeat-containing protein 79;WD40 repeat-containing protein encoding RNA antisense to p53
Recombinant Proteins
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Human
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
WRAP53 involved in several pathways and played different roles in them. We selected most pathways WRAP53 participated on our site, such as Cell Cycle,Chromosome Maintenance,Extension of Telomeres, which may be useful for your reference. Also, other proteins which involved in the same pathway with WRAP53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extension of Telomeres | DKC1,RUVBL2 |
| Telomere Extension By Telomerase | DKC1 |
| Chromosome Maintenance | CENPW,TINF2,ITGB3BP,DKC1,MLF1IP,APITD1,TERF2,RUVBL2,HJURP,CENPC1 |
| Cell cycle | RAD9B,ARF1,SDCCAG8,ESCO2,CSNK2A2,FZR1A,CETN2,POT1,ORC2,EP300 |
| Telomere Maintenance | DKC1 |
Protein Function
WRAP53 has several biochemical functions, for example, RNA binding,protein binding,telomerase RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WRAP53 itself. We selected most functions WRAP53 had, and list some proteins which have the same functions with WRAP53. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RHBDL1,RUSC2,HTR3C,GNMT,FAN1,SFTPC,MGST1,EPB41,MICAL1,C19orf44 |
| telomerase RNA binding | NHP2,TERT,HNRNPC,PINX1,GAR1,DKC1,HNRNPU,NOP10 |
| RNA binding | ARHGEF28,SRSF9,THOC3,UNC50,IFIT10,QKIA,DOM3Z,MIF4GD,MOV10B.1,NOVA2 |
Interacting Protein
WRAP53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WRAP53 here. Most of them are supplied by our site. Hope this information will be useful for your research of WRAP53.
DKC1;terc_human_rna;TCP1;CCT3;CCT2
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References
- Garvin, S; Tiefenbock, K; et al. Nuclear expression of WRAP53 beta is associated with a positive response to radiotherapy and improved overall survival in patients with head and neck squamous cell carcinoma. ORAL ONCOLOGY 51:24-30(2015).
- Henriksson, S; Rassoolzadeh, H; et al. The scaffold protein WRAP53 beta orchestrates the ubiquitin response critical for DNA double-strand break repair. GENES & DEVELOPMENT 28:2726-2738(2014).
