WNT4
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Official Full Name
wingless-related MMTV integration site 4 -
Overview
The evolutionarily conserved WNT (Wingless-type MMTV integration site family) signaling pathway has diverse roles in governing cell fate, proliferation, migration, polarity and death. WNT signaling controls development and is important for embryogenesis a -
Synonyms
WNT4;wingless-related MMTV integration site 4;protein Wnt-4;signal molecule;Wnt-4;MGC123964;SERKAL
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- HEK293T
- E.coli
- E. coli
- CHO
- Mammalian Cell
- HEK293
- Human Cells
- Insect Cells
- N-Fc-Flag
- His
- N-GST
- Non
- His&GST
- His&Fc&Avi
- Fc
- His&SUMO
Involved Pathway
WNT4 involved in several pathways and played different roles in them. We selected most pathways WNT4 participated on our site, such as Wnt signaling pathway,Hedgehog signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hedgehog signaling pathway | SMO,SKI,PRKACB,DHH,PRKACBB,LRP2A,CSNK1G2B,GLI2B,GLI2,WNT2 |
| Pathways in cancer | Casp3,GRB2,PTGER4,SMAD4,ABL1,NRAS,PAX8,PLCB4,BIRC7,WNT9A |
| Thyroid hormone signaling pathway | HDAC3,MED1,SLC9A1,ATP2A2,PRKCB,SLC16A2,PRKACB,PRKCG,NCOA3,RXRA |
| Signaling pathways regulating pluripotency of stem cells | SMAD5,HOXB1,ID4,AXIN1,IL6ST,WNT7B,RAF1,WNT2B,POU5F1,SMARCAD1 |
| HTLV-I infection | KAT2B,ZFP36,ATF3,STAT5B,FOS,CRTC2,WNT9B,IL6,PRKACA,VDAC3 |
| Wnt signaling pathway | DAAM1,PPP3CCA,PLCB3,RAC1,WNT5B,FZD8A,PRICKLE2B,SFRP2,WNT2BB,SOX17 |
| Melanogenesis | CALM1,DCT,RAF1B,WNT9B,CALML5,MAP2K2,CALM3,DVL1B,ASIP,RAF1A |
| Hippo signaling pathway | TGFBR1,STK3,NKD1,WNT10B,APC2,CRB2,WNT2,WNT9A,WNT2B,WNT9B |
| Basal cell carcinoma | PTCH2,WNT8A,WNT7B,HHIP,WNT3,LEF1,Shh,WNT3A,WNT9A,DVL3 |
Protein Function
WNT4 has several biochemical functions, for example, frizzled binding,receptor agonist activity,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT4 itself. We selected most functions WNT4 had, and list some proteins which have the same functions with WNT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| frizzled binding | WNT8A,WNT10B,FZD7,WNT2BA,MYOC,WNT7A,WNT6,WNT4B,WNT5B,WNT3A |
| transcription corepressor activity | ATF3,BCOR,BHLHE40,SKOR1,NSD1,NR0B2A,HEYL,SIRT1,LOXL2,GPS2 |
| receptor agonist activity | WNT8A,VEGFA,GAS6,WNT7A,WNT3,WNT3A,SFRP2,GREM1,WNT5A,WNT2 |
Interacting Protein
WNT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT4.
P2RX4
WNT4 Related Signal Pathway
Resources
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References
- Morizane, R; Monkawa, T; et al. Kidney Specific Protein-Positive Cells Derived from Embryonic Stem Cells Reproduce Tubular Structures In Vitro and Differentiate into Renal Tubular Cells. PLOS ONE 8:-(2013).
- Murugan, S; Shan, JD; et al. WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis. EXPERIMENTAL CELL RESEARCH 318:1134-1145(2012).
