WNT2
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Official Full Name
wingless-type MMTV integration site family member 2 -
Synonyms
WNT2;wingless-type MMTV integration site family member 2;INT1L1;protein Wnt-2;IRP;secreted growth factor;int-1-like protein 1;Int-1-related protein
Recombinant Proteins
- Mouse
- Rhesus macaque
- Zebrafish
- Human
- Mammalian Cells
- HEK293
- CHO
- E.coli
- Yeast
- Insect Cells
- His
- Non
- His&Fc&Avi
Involved Pathway
WNT2 involved in several pathways and played different roles in them. We selected most pathways WNT2 participated on our site, such as Wnt signaling pathway,Hedgehog signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | PRKACG,PIK3CG,PRKACA,FZD7,GAB1,MAPK1,RRAS2,CAV3,FZD1,ESR1 |
| Pathways in cancer | STAT5B,TRAF3,RAC1,FGF17,FADD,PRKACG,PDGFRA,RXRG,CSF1R,FGF4 |
| Hippo signaling pathway | SERPINE1,TGFBR2,WTIP,SMAD1,FZD9,AXIN1,CCND3,PPP2R1A,CTNNA2,PPP2CB |
| Hedgehog signaling pathway | WNT11R,GLI3,PRKACAB,PRKACBB,DYRK1AA,IHHA,WNT8B,FBXW11A,BMP4,LRP2 |
| Wnt signaling pathway | PPP3R2,SMAD3,CSNK1A1L,FZD2,RAC3,WNT9A,RHOA,TCF7,GSK3AA,FBXW2 |
| Basal cell carcinoma | WNT3A,AXIN2,WNT8A,BMP2,WNT1,WNT8B,WNT9B,FZD10,WNT4,DVL1 |
| HTLV-I infection | WNT6,FZD10,TGFB3,NRAS,ITGAL,RB1,IKBKB,WNT8A,HLA-DMA,IL2RG |
| Melanogenesis | CREB3L3A,EDNRB2,WNT2BB,MITF,LEF1,MC1R,GNA15.1,WNT3A,WNT7B,POMC |
| Signaling pathways regulating pluripotency of stem cells | PIK3CD,WNT7A,KRAS,HAND1,IGF1,PCGF6,WNT5A,ACVR2B,WNT9A,SMARCAD1 |
Protein Function
WNT2 has several biochemical functions, for example, cytokine activity,frizzled binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT2 itself. We selected most functions WNT2 had, and list some proteins which have the same functions with WNT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| frizzled binding | WNT2B,WNT1,WNT6,WNT4B,DVL3A,WNT4,ZNRF3,RNF43,DVL2,WNT2BA |
| protein binding | PSMD5,RAB39B,SLC7A1,ASS1,PRELID1,MED28,MYLIPA,DHX30,NUP107,ANKFY1 |
| cytokine activity | Ifnz,HMGB1B,TNFSF8,GDF6,BMP8B,IL21,NDP,BMP2,IFNA1,Il23a; Il12b |
| receptor agonist activity | WNT3,NODAL,CXCL13,WNT3A,WNT7A,VEGFA,WNT1,WNT4,GAS6,GREM1 |
Interacting Protein
WNT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT2.
SFRP1;UQCR11;HCK;AQP5;RRAGC
WNT2 Related Signal Pathway
Resources
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References
- Li, QS; Yu, P; et al. GENE EXPRESSION PROFILES OF VARIOUS CYTOKINES IN MESENCHYMAL STEM CELLS DERIVED FROM UMBILICAL CORD TISSUE AND BONE MARROW FOLLOWING INFECTION WITH HUMAN CYTOMEGALOVIRUS. CELLULAR & MOLECULAR BIOLOGY LETTERS 19:140-157(2014).
- Chen, J; Fu, L; et al. IDENTIFICATION OF ANTI-WNT2 MOUSE MONOCLONAL ANTIBODY AS A TARGETED ANTICANCER THERAPY IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA. ANNALS OF ONCOLOGY 24:25-25(2013).
