WNT10B
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Official Full Name
wingless-type MMTV integration site family, member 10B -
Overview
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. -
Synonyms
WNT10B;wingless-type MMTV integration site family, member 10B;protein Wnt-10b;SHFM6;WNT 12;WNT-10B protein;WNT-12
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- CHO
- Mammalian Cell
- HEK293
- E.coli
- Wheat Germ
- Mammalian cells
- Non
- His
- His&Fc&Avi
- His&T7
- GST
- His&Myc
Involved Pathway
WNT10B involved in several pathways and played different roles in them. We selected most pathways WNT10B participated on our site, such as Wnt signaling pathway,Hedgehog signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT10B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | ROCK2,HGF,IGF1R,RHOA,WNT1,CTTN,FGFR1,CBLB,MAPK13,TIMP3 |
| Wnt signaling pathway | SFRP1,SOX17,MMP7,NFATC2,FBXW2,PPP3CCA,DKK1,NFATC1,PPP3CCB,WNT11B |
| Hippo signaling pathway | ACTG1,CCND1,TCF7,FZD3,BBC3,YWHAZ,GDF6,LLGL2,PPP2R2A,BMP7 |
| Signaling pathways regulating pluripotency of stem cells | PCGF1,MAPK1,WNT7A,FZD2,BMPR2,WNT9B,MAPK11,SMAD1,SETDB1,SMAD3 |
| Pathways in cancer | PLCB2,ITGA6,MSH2,CCDC6,TGFB1,FZD10,PLCB4,FGF3,FGF10,RAF1 |
| Basal cell carcinoma | WNT5A,TCF7L2,WNT8B,FZD5,WNT9B,WNT5B,GSK3B,GLI3,WNT8A,FZD9 |
| Hedgehog signaling pathway | WNT6,ZIC2B,FBXW11A,GSK3B,PRKACG,PRKACAA,DYRK1AA,IHH,ZIC2A,WNT2BB |
| Melanogenesis | TCF7,WNT5A,GNA15.4,FZD8B,KITB,ADCY1B,WNT8A,Adcy4,CAMK2G1,ASIP |
| HTLV-I infection | IL6,TP53INP1,CANX,PPP3CB,PDGFA,ICAM1,HLA-DRB4,HLA-DQA1,HLA-DRA,TNF |
Protein Function
WNT10B has several biochemical functions, for example, frizzled binding,receptor agonist activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT10B itself. We selected most functions WNT10B had, and list some proteins which have the same functions with WNT10B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor agonist activity | VEGFA,WNT5A,WNT3,WNT7A,WNT1,CXCL13,WNT4,WNT2,WNT8A,NODAL |
| frizzled binding | WNT7AA,WNT8B,NDP,WNT2B,WNT11,SFRP1,WNT9B,WNT4,DVL1,WNT2BA |
Interacting Protein
WNT10B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT10B here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT10B.
WNT10B Related Signal Pathway
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References
- Tyagi, AM; Mansoori, MN; et al. Enhanced Immunoprotective Effects by Anti-IL-17 Antibody Translates to Improved Skeletal Parameters Under Estrogen Deficiency Compared With Anti-RANKL and Anti-TNF-alpha Antibodies. JOURNAL OF BONE AND MINERAL RESEARCH 29:1981-1992(2014).
- Li, JY; Walker, LD; et al. The Sclerostin-Independent Bone Anabolic Activity of Intermittent PTH Treatment Is Mediated by T-Cell-Produced Wnt10b. JOURNAL OF BONE AND MINERAL RESEARCH 29:43-54(2014).
