WHSC2
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Official Full Name
Wolf-Hirschhorn syndrome candidate 2 -
Overview
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. -
Synonyms
WHSC2;Wolf-Hirschhorn syndrome candidate 2;negative elongation factor A;NELF A;FLJ10442;FLJ25112;Negative elongation factor polypeptide A;NELFA;P/OKcl.15;P/OKcl15;WHSC 2;Wolf Hirschhorn syndrome candidate 2;Wolf Hirschhorn syndrome candidate 2 protein;wolf-Hirschhorn syndrome candidate 2 protein;NELF-A
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- E.coli
- HEK293
- His
- T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| WHSC2-18547M | Recombinant Mouse WHSC2 Protein | Mammalian Cell | Mouse | His |
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| WHSC2-3015H | Recombinant Human Wolf-Hirschhorn Syndrome Candidate 2, T7-tagged | E.coli | Human | T7 |
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| WHSC2-30860TH | Recombinant Human WHSC2, His-tagged | E.coli | Human | His | 539 amino acids |
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| WHSC2-3397H | Recombinant Human Wolf-Hirschhorn Syndrome Candidate 2, His-tagged | E.coli | Human | His |
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| WHSC2-1932HCL | Recombinant Human WHSC2 cell lysate | Human | Non |
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| WHSC2-10179M | Recombinant Mouse WHSC2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| WHSC2-10179M-B | Recombinant Mouse WHSC2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
WHSC2 involved in several pathways and played different roles in them. We selected most pathways WHSC2 participated on our site, such as Abortive elongation of HIV-1 transcript in the absence of Tat,Disease,Formation of HIV elongation complex in the absence of HIV Tat, which may be useful for your reference. Also, other proteins which involved in the same pathway with WHSC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Abortive elongation of HIV-1 transcript in the absence of Tat | TH1L,RDBP,SUPT4H1,CTDP1,COBRA1,SUPT5H |
| Formation of HIV elongation complex in the absence of HIV Tat | ELL,SSRP1,PSTPIP2,TCEA1,SUPT5H,CTDP1,SUPT4H1,TH1L,COBRA1,TCEB3 |
| Formation of the Early Elongation Complex | TH1L,SUPT4H1,GM3258,RDBP,COBRA1,NELFE,CTDP1,SUPT5H |
| Disease | SSRP1,HMGA1,CTDP1,PPIAL4A,APOBEC3G,HDAC6,TIRAP,NUP35,CPSF6,AP2A1 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | CDK9,SSRP1,RDBP,TCEB3,TH1L,TCEA1,CTDP1,SUPT4H1,SUPT5H,ELL |
| Gene Expression | EIF2S1,NR4A2A,ZNF705A,NR2F1A,ADARB1A,TAF1B,TAF1A,ZFP90,XPOT,ZNF549 |
| Formation of RNA Pol II elongation complex | SUPT16H,NELFE,TH1L,CTDP1,GM3258,SUPT5H,TCEA1,TCEB3,SUPT4H1,CDK9 |
| Formation of the HIV-1 Early Elongation Complex | CTDP1,SUPT5H,SUPT4H1,RDBP,COBRA1,TH1L |
Protein Function
WHSC2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WHSC2 itself. We selected most functions WHSC2 had, and list some proteins which have the same functions with WHSC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TFCP2,TSG101,SLIRP,LXN,HLA-DRB4,WRAP53,CPSF2,PCNP,TPI1,DNER |
Interacting Protein
WHSC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WHSC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WHSC2.
NELFCD;NELFE;NELFB;163154;SIAH1;NELFCD
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