VLDLR
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Official Full Name
Very Low Density Lipoprotein Receptor -
Overview
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. -
Synonyms
FLJ35024;Very low density lipoprotein receptor;VLDL R;VLDLRCH;VLDLR
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Chicken
- E.coli
- HEK293
- Mammalian cells
- Mammalian Cell
- Human Cell
- GST
- His
- His&T7
- Non
- His&Fc&Avi
- Fc
Involved Pathway
VLDLR involved in several pathways and played different roles in them. We selected most pathways VLDLR participated on our site, such as Lissencephaly gene (LIS1) in neuronal migration and development,Reelin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with VLDLR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lissencephaly gene (LIS1) in neuronal migration and development | LRPAP1,DAB1,NUDC,DYNLT1,MAP1B,DCX,KATNA1,NDEL1 |
| Reelin signaling pathway | DAB1,LRPAP1,MAP1B |
Protein Function
VLDLR has several biochemical functions, for example, apolipoprotein binding,calcium ion binding,calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VLDLR itself. We selected most functions VLDLR had, and list some proteins which have the same functions with VLDLR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| apolipoprotein binding | SCARB1,LRP6,LRP4,LPL,LPA,PLG,ABCA1,LRP1,LIPC,CANX |
| glycoprotein transporter activity | ABCG1 |
| calcium ion binding | SNED1,AOC3,SULF1,SYTL3,PITPNM3,CAPN11,S100A13,PLCD1A,PVALB1,PCDH1G32 |
| protein binding | PXMP2,PITPNM3,ZBTB32,HPCAL1,POMGNT1,FYCO1,YY1,NEDD8,TAF6,NCDN |
| glycoprotein binding | HFE2,LDLR,RASA1,FBXO2,FBXO17,FGFR1,CNTN1,CANX,PTBP3,ERBB2 |
| very-low-density lipoprotein particle binding | PCSK9 |
| very-low-density lipoprotein particle receptor activity | APOBR,LDLR |
| calcium-dependent protein binding | S100A1,VPS37C,RAC3,A2M,PDCD6IP,STMN2,CALM1,SYT1,CPNE3,MYO5A |
| low-density lipoprotein receptor activity | LRP12,OLR1,LDLR,CXCL16,LRP6 |
Interacting Protein
VLDLR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VLDLR here. Most of them are supplied by our site. Hope this information will be useful for your research of VLDLR.
LRPAP1;Reln;Lrpap1
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