VASP

  • Official Full Name

    VASP vasodilator-stimulated phosphoprotein

  • Overview

    VASP (vasodilator stimulated phosphoprotein) plays an important role in ANF/NO/cGMP Protein kinase and cAMP/cAMP Protein kinase signalling pathways. VASP is expressed in almost all human and animal cell lines; particularly high concentrations are found in thrombocytes, vascular smooth muscle cells and fibroblasts. In cultured cells VASP is associated with focal contacts, cell-cell-contacts, microfilaments and dynamic membrane regions such as the leading edge. In vitro binding data show that VASP binds to profilin, zyxin, vinculin, and the Listeria spp. surface protein ActA. Functional evidence indicates that VASP is a crucial factor involved in the enhancement of actin filament formation.

  • Synonyms

    VASP;vasodilator-stimulated phosphoprotein

Recombinant Proteins

  • Mouse
  • Human
  • Mammalian Cell
  • E.coli
  • HEK293
  • Mammalian cells
  • HEK293T
  • His
  • Non
  • Flag
  • Myc&DDK
  • His&Fc&Avi

    Involved Pathway

    VASP involved in several pathways and played different roles in them. We selected most pathways VASP participated on our site, such as Rap signaling pathway,cGMP-PKG signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with VASP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Platelet activation GUCY1A3,PLCB2,FGG,PPP1CA,F2R,PPP1CB,PLCB4,RAP1A,RHOA,GNAQ
    cGMP-PKG signaling pathway NPR2,ATP1B3,GATA4,PIK3R5,PPP3CA,AGTR1B,MEF2C,ITPR1,ATP2A1,LOC100328615
    Rap signaling pathway CALM4,VEGFB,PRKD3,F2R,FGF18,PFN3,IGF1R,PIK3R2,ANGPT2,CDH1
    Fc gamma R-mediated phagocytosis PIK3R5,FCGR1,PLA2G4D,ARPC1A,HCK,LIMK2,AMPH,AKT1,AKT2,PLD1
    Focal adhesion ITGA2,DIAP1,VEGFC,ACTB2,PDGFB,ROCK2B,BIRC2,FLNC,MYLK3,LAMB3
    Leukocyte transendothelial migration CLDN16,CXCL12,MYL5,ITGAM,PLCG1,CLDN8,RHOH,CXCR4,ITGB2L,JAM2

    Protein Function

    VASP has several biochemical functions, for example, SH3 domain binding,actin binding,profilin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VASP itself. We selected most functions VASP had, and list some proteins which have the same functions with VASP. You can find most of the proteins on our site.

    Function Related Protein
    protein binding RAB6A,KRTAP19-5,C7orf42,RTDR1,SMAD7,PPIF,TMED5,AP2B1,EFHC2,DNAJB2
    SH3 domain binding INPPL1B,ABI2,MYPN,ADAM19,VASPA,INPPL1,QKI2,USP8,EPS15,ADAM9
    profilin binding RHOQ,FMNL1,WIPF1,DIAP1,CTTN,PCLO,CYFIP1,HTT,EVL,DIAPH1
    actin binding MYH7,ACTR3B,ADD3,FHOD3,LSP1,PARVAB,MPRIP,PLECA,GSNA,MICAL2

    Interacting Protein

    VASP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VASP here. Most of them are supplied by our site. Hope this information will be useful for your research of VASP.

    XIRP1;BAIAP2;FGFR1OP;SCGB2A2;ABI2

    Resources

    Research Area

    Platelet Markers

    References

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