USP1
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Official Full Name
ubiquitin specific peptidase 1 -
Overview
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] -
Synonyms
USP1;ubiquitin specific peptidase 1;UBP;ubiquitin carboxyl-terminal hydrolase 1;hUBP;ubiquitin thioesterase 1;deubiquitinating enzyme 1;ubiquitin thiolesterase 1;ubiquitin specific protease 1;ubiquitin carboxyl terminal hydrolase 1;ubiquitin specific processing protease 1;ubiquitin-specific-processing protease 1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Zebrafish
- E.coli
- Sf21 Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- Insect Cell
- GST
- His
- His&T7
- Myc&DDK
- Non
- His&Fc&Avi
Involved Pathway
USP1 involved in several pathways and played different roles in them. We selected most pathways USP1 participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | BRIP1,TOP3B,HES1,FANCG,UBE2T,RPA4,PMS2,FANCL,FANCI,FAN1 |
Protein Function
USP1 has several biochemical functions, for example, cysteine-type endopeptidase activity,protein binding,ubiquitin-specific protease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP1 itself. We selected most functions USP1 had, and list some proteins which have the same functions with USP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-specific protease activity | TNFAIP3,ZRANB1B,ATXN3,USP12,USP31,USP17L2,USP14,FMNL3,BAP1,USP16 |
| protein binding | XPA,IL6,RPP25L,NR3C2,NUMA1,NRIP2,RPSA,SEC16B,CRYBB1,ANLN |
| cysteine-type endopeptidase activity | USP37,CTSLL,USP15,PSD,USP12A,CTSL1,CTSW,Casp3,ATG4B,FAM49BA |
Interacting Protein
USP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP1.
KPNA1;ANXA2P2;c9jh30_human;PHLPP1;HSPB1;JUP;KRT4;FLG;CALML3;MYH9;TAGLN2;LGALS7B;LYZ;DSG1;KRT17;DSC1;USP4;PKP1
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