ULK2
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Official Full Name
unc-51-like kinase 2 (C. elegans) -
Overview
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. -
Synonyms
ULK2;unc-51-like kinase 2 (C. elegans);unc 51 (C. elegans) like kinase 2;serine/threonine-protein kinase ULK2;ATG1B;KIAA0623;Unc51.2;Serine/threonine protein kinase ULK2;ULK2_HUMAN;Unc 51 like kinase 2;Unc-51-like kinase 2;OTTHUMP00000065847;OTTHUMP00000065848
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ULK2-456H |
Active Recombinant Human ULK2 protein, GST-tagged
|
Insect Cell | Human | GST | 1-478 a.a. |
|
| ULK2-1115H | Recombinant Human Unc-51-Like Kinase 2 (C. elegans), GST-tagged | Sf10 Insect Cell | Human | GST | 1-478 a.a. |
|
| ULK2-504HCL | Recombinant Human ULK2 293 Cell Lysate | HEK293 | Human | Non |
|
Involved Pathway
ULK2 involved in several pathways and played different roles in them. We selected most pathways ULK2 participated on our site, such as Regulation of autophagy,mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ULK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mTOR signaling pathway | AKT1,ULK1,PTENA,RRN3,TSC2,PIK3R2,IRS1,PRKCA,PRR5,PTEN |
| Regulation of autophagy | ATG13,INS2,PRKAA2,Ifna15,ATG7,ATG4A,GABARAP,GABARAPA,ATG4C,ATG4D |
Protein Function
ULK2 has several biochemical functions, for example, ATP binding,protein binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ULK2 itself. We selected most functions ULK2 had, and list some proteins which have the same functions with ULK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | STK35L,DCLK3,STK11,LATS1,DCKL1B,CHEK2,ACVR2AA,STK32B,ACVR1L,DYRK2 |
| ATP binding | CCT6B,ATP1A1A.5,ZAK,RPS6KA5,OPLAH,UBE2L3,ACSM2,MAST4,BCR,SPEG |
| protein binding | NFKBIZ,HPS1,NTN4,FLVCR1,COX6B2,FAM81B,C1R,CEP104,GRK5,YWHAE |
Interacting Protein
ULK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ULK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ULK2.
RB1CC1;GABARAP;IRF1;GABARAPL2;MAP1LC3B;GABARAPL1;ZNF32;EEF1B2;NASP;POLA2;SETDB1;DIXDC1;LNX1;LUC7L2;PRKAB2
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References
- Lee, S; Page-McCaw, P; et al. Kctd12 and Ulk2 Partner to Regulate Dendritogenesis and Behavior in the Habenular Nuclei (vol 9, e110280, 2014). PLOS ONE 10:-(2015).
- Huang, YH; Huang, XH; et al. Involvement of fish signal transducer and activator of transcription 3 (STAT3) in nodavirus infection induced cell death. FISH & SHELLFISH IMMUNOLOGY 43:241-248(2015).
