UL55
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Official Full Name
envelope glycoprotein B -
Overview
Human cytomegalovirus(CMV) (human herpesvirus 5) glycoprotein B is a 907-amino acid glycoprotein encoded by the ORF of UL55. It is the most abundant component of the envelope with at least two defined neutralizing epitopes, a target of neutralizing antibodies and an essential replication component. The synthesized gB precursor matures into a 130-160 kDa glycoprotein by acquiring N-linked glycosylation modifications, and is cleaved by the cellular protease furin into two components, a 93-116 kDa N-terminal fragment and a 55 kDa C-terminal fragment linked by a disulfide-bond, which is presented on the viral envelope as well as on the surface of virus-infected cells as a covalently associated homodimer. gB plays important roles in HCMV entry, cell-cell spread of internal virions, and fusion of infected cells. It triggers penetration of cells and enhances the spread of infection in nonpolarized human fibroblasts. -
Synonyms
UL55;type 1 membrane protein;possible membrane fusogen;binds cell surface heparan sulphate;involved in cell entry;involved in cell-to-cell spread;envelope glycoprotein B
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UL55-179C | Recombinant CMV UL55 | Human Cell | CMV | Non | Met1-Lys700 & Arg777-Val907 |
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| UL55-180C | Recombinant Cytomegalovirus UL55 protein, Fc-tagged | HEK293 | Cytomegalo Virus | Fc | Met 1-Lys 700 |
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| UL55-181C | Recombinant Cytomegalovirus UL55 protein, Fc-tagged | HEK293 | Cytomegalo Virus | Fc | Met 1-Lys 700 |
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| UL55-3328H | Recombinant Human Cytomegalovirus UL55, His-tagged | Human Cell | Human | His |
|
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| UL55-1562H | Recombinant HHV-5 UL55 Protein (Ser24-Pro706), C-His tagged | Baculovirus-Insect cells | HHV5 | His | Ser24-Pro706 |
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Involved Pathway
UL55 involved in several pathways and played different roles in them. We selected most pathways UL55 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UL55 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
UL55 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by UL55 itself. We selected most functions UL55 had, and list some proteins which have the same functions with UL55. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
UL55 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UL55 here. Most of them are supplied by our site. Hope this information will be useful for your research of UL55.
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