UHRF1
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Official Full Name
ubiquitin-like, containing PHD and RING finger domains, 1 -
Overview
DNA methylation inheritance is the process of copying pre-existing methylation patterns onto newly replicated DNA strand after DNA replication. Dnmt1 is the DNA methyltransferase that methylate hemi-methylated CpG region, which occurs after DNA repairs an -
Synonyms
UHRF1;ubiquitin-like, containing PHD and RING finger domains, 1;E3 ubiquitin-protein ligase UHRF1;nuclear protein 95;nuclear zinc finger protein Np95;ubiquitin-like PHD and RING finger domain-containing protein 1;ubiquitin-like-containing PHD and RI
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- GST
- Non
- Flag
- His&Fc&Avi
Involved Pathway
UHRF1 involved in several pathways and played different roles in them. We selected most pathways UHRF1 participated on our site, such as DNA methylation,Epigenetic regulation of gene expression,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with UHRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epigenetic regulation of gene expression | AEBP2,TET3,DNMT3A,JARID2,SUZ12B,SMARCA5,DNMT1,TET1,JARID2B,CD3EAP |
| Gene Expression | ZNF192,ADAT3,APEH,PTRFB,HNRNPA0,TEAD1A,DCP2,SPCS3,USP9X,ZNF227 |
| DNA methylation | DNMT3B,DNMT1,DNMT3L,DNMT3A |
Protein Function
UHRF1 has several biochemical functions, for example, core promoter proximal region sequence-specific DNA binding,hemi-methylated DNA-binding,histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UHRF1 itself. We selected most functions UHRF1 had, and list some proteins which have the same functions with UHRF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | ZNRF2,RNF133,MARCH4,HERC2,CTPS1A,CBX4,ITCH,MGRN1,RNF182,BARD1 |
| ubiquitin-protein transferase activity | MARCH8,NSMCE1,NHLRC1,ARIH1L,UBE2D2,STUB1,MARCH6,PRP19,FBXO22,FBXW2 |
| methyl-CpG binding | MBD1B,DNMT1,MECP2,ZNF295,MBD3B,ZBTB33,MBD1,MBD3L1,MBD3A,LRWD1 |
| histone binding | RAG1,HIST3H3,TBL1XR1,CTCFL,HIST1H4J,L3MBTL1,AIRE,PRKCBB,UIMC1,HIST1H3F |
| ubiquitin protein ligase activity | RNF7,ZNRF2,UBE2S,MED21,PDZD4,UBE2H,WWP1,FBXO6,BRAP,HERC2 |
| zinc ion binding | RBM5,SREK1IP1,APOBEC2A,PARP1,MARCH11,ARHGEF2,TRIM35-35,ZCCHC18,BMP1A,LMO4A |
| nucleosomal histone binding | L3MBTL1,VRK1 |
| protein binding | SGTB,CBS,Akap3,HIRIP3,C9orf78,PIK3CB,ZNF238,TFG,TGFB1I1,CST2 |
| identical protein binding | SF1,GYPA,TRIM5,AIRE,CEACAM5,NUFIP1,C10orf88,DPP9,COIL,CALHM1 |
Interacting Protein
UHRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UHRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UHRF1.
DNMT1;DNMT3B;DNMT3A
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References
- Marjoram, L; Alvers, A; et al. Epigenetic control of intestinal barrier function and inflammation in zebrafish. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:2770-2775(2015).
- Jung, YD; Shim, JW; et al. Downregulation of UHRF1 promotes EMT via inducing CXCR4 in human cancer cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1232-1242(2015).
