UHMK1
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Official Full Name
U2AF homology motif (UHM) kinase 1 -
Overview
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. -
Synonyms
UHMK1;U2AF homology motif (UHM) kinase 1;serine/threonine-protein kinase Kist;KIS;Kist;KIS protein kinase;kinase interacting with leukemia-associated gene (stathmin);FLJ23015;DKFZp434C1613
Recombinant Proteins
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
UHMK1 involved in several pathways and played different roles in them. We selected most pathways UHMK1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UHMK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
UHMK1 has several biochemical functions, for example, ATP binding,mRNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UHMK1 itself. We selected most functions UHMK1 had, and list some proteins which have the same functions with UHMK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TGFB2,CA2,GPRC5A,IGFL1,ING1,RIPK2,SMNDC1,RGS7BP,SMARCA4,CISD2 |
| ribonucleoprotein complex binding | SRP54A,TIMM50,PQBP1,SECISBP2,RNF135,PRPF31,PES,IFIH1,PRMT7,SRP54 |
| protein serine/threonine kinase activity | PKMYT1,PAK3,RPS6KA1,STK30,MAP2K2,CAMK1DB,TGFBR1,ALPK2,ULK2,STK3 |
| mRNA binding | C1QBP,PAIP2,NANOS2,AGO2,CSTF2,SLBP,PIWIL1,MRPS7,IGF2BP1,SNRNP70 |
| ATP binding | BLM,ITPKA,PMELA,HSP70,UBE2G1B,SMC1AL,ADRBK1,SCYL1,MTHFS,NADSYN1 |
| transferase activity | TAOK3,NAT15,GYG1A,MKNK2A,PCMT,GLT25D2,MARCKSB,FKTN,EHMT1A,FYNB |
Interacting Protein
UHMK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UHMK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UHMK1.
ABL1;SF1
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References
- Manceau, V; Swenson, M; et al. Major phosphorylation of SF1 on adjacent Ser-Pro motifs enhances interaction with U2AF(65). FEBS JOURNAL 273:577-587(2006).
- Loerch, S; Maucuer, A; et al. Cancer-relevant Splicing Factor CAPER alpha Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex. JOURNAL OF BIOLOGICAL CHEMISTRY 289:17325-17337(2014).
- Puri, V; McQuillin, A; et al. Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3. EUROPEAN JOURNAL OF HUMAN GENETICS 16:1275-1282(2008).
