UCHL3
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Official Full Name
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -
Overview
The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are;proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the;mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to;regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that;encode different protein isoforms. -
Synonyms
UCHL3;ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase);ubiquitin carboxyl-terminal hydrolase isozyme L3;ubiquitin thiolesterase;ubiquitin thioesterase L3;UCH-L3
Recombinant Proteins
- Mouse
- Rat
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- E.coli
- Human
- Mammalian Cell
- HEK293
- Rabbit
- Mammalian cells
- HEK293T
- E. coli
- His
- GST
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
UCHL3 involved in several pathways and played different roles in them. We selected most pathways UCHL3 participated on our site, such as Proteasome Degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCHL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome degradation | STUB1,ASB6,LRSAM1,UBE2J2,ARIH2,TRIM63,RNF220,TRIM9,RNF123,RNF25 |
Protein Function
UCHL3 has several biochemical functions, for example, peptidase activity,protein binding,ubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UCHL3 itself. We selected most functions UCHL3 had, and list some proteins which have the same functions with UCHL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-specific protease activity | USP19,EIF3F,STAMBP,USP2A,ATXN3L,USP5,CYLD,OTUD6A,USP34,USP48 |
| ubiquitin binding | KCNS1,RNF168,OTUB1A,UBXN11,TRIM32,FAN1,FAF2,USP25,NSFL1C,FAM125A |
| protein binding | SMARCB1,PACSIN3,ALK,CASP8,MAP3K5,GPR19,TUBGCP3,KARS,MAGEA6,APBB1IP |
| peptidase activity | REN,KLK7,CASPB,Gzmg,USP43,PCSK5,KEX2,ZRANB1B,PRSS28,TMPRSS12 |
Interacting Protein
UCHL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCHL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCHL3.
UBB;Smad1;SMAD1;COPS6;COPS5;CLPB;USP20;ATXN7L3;POGK;NSG2;pi3p
Resources
Research Area
Parkinson's Disease Related MoleculesUbiquitin-related Molecules in the Akt Pathway
Deubiquitinating Enzymes (DUBs)
Related Services
Related Products
References
- Sarveswari, S; Vijayakumar, V; et al. Synthesis of 4-Hydroxy-2(1H)-Quinolone Derived Chalcones, Pyrazolines and Their Antimicrobial, In Silico Antimalarial Evaluations. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 175:43-64(2015).
- Hung, FF; To, WP; et al. Water-Soluble Luminescent Cyclometalated Gold(III) Complexes with cis-Chelating Bis(N-Heterocyclic Carbene) Ligands: Synthesis and Photophysical Properties. CHEMISTRY-A EUROPEAN JOURNAL 20:8604-8614(2014).
