UBTF
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Official Full Name
upstream binding transcription factor, RNA polymerase I -
Overview
The eukaryotic upstream binding factor (UBF), recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor, SL1. UBF binds specifically to the upstream control element and core of the rRNA gene promoter to activate transcription in a binding site-dependent manner (1). Experiments reveal that a cooperative interaction between UBF and SL1 leads to the formation of a new protein-DNA complex at the UCE and core elements which indicate that formation of the UBF-SL1 complex is vital for transcriptional activation by UBF (2). UBF contains six HMG box domains. The contribution of each HMG box motif to its function is different (3). Its believed that HMG motifs are the DNA-binding domains of UBF. Altering one of these boxes, as in the second form of UBF, may alter the functional characteristics of the transcription factor. Thus, the existence of different forms of UBF may have important ramifications for transcription by RNA polymerase I (4). -
Synonyms
UBTF;upstream binding transcription factor, RNA polymerase I;nucleolar transcription factor 1;NOR 90;UBF;autoantigen NOR-90;90-kDa nucleolus organizer region autoantigen;UBF1;UBF-1;NOR-90
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Mammalian Cell
- Baculovirus-Insect cells
- E.coli
- HEK293
- Yeast
- His
- His&SUMO
- Myc&DDK
- His&Fc&Avi
Involved Pathway
UBTF involved in several pathways and played different roles in them. We selected most pathways UBTF participated on our site, such as Gene Expression,RNA Polymerase I Chain Elongation,RNA Polymerase I Promoter Clearance, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBTF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA Polymerase I Promoter Escape | TAF1C,TAF1B,TAF1D,EFCAB11,TAF1A,CD3EAP,RRN3 |
| RNA Polymerase I Chain Elongation | EFCAB11,TAF1C,CBX3A,CD3EAP,CBX3,TAF1B,TAF1A,TAF1D |
| Gene Expression | RRP8,VDRB,ZNF433,NRBP1,ZNF286A,RPP40,SLC38A8,EARS2,TNRC6B,ZFP2 |
| RNA Polymerase I Promoter Clearance | GATAD2A,CHD4A,EFCAB11,EHMT2,MTA2,GATAD2AB,MTA3,MBD3A,CD3EAP,GATAD2B |
| RNA Polymerase I Transcription Termination | PTRF,PTRFB |
| RNA Polymerase I Transcription | MTA1,CBX3A,GATAD2A,MTA3,PTRF,TAF1A,MBD3A,GATAD2AB,EFCAB11,PTRFB |
| RNA Polymerase I Transcription Initiation | MTA1,GATAD2AB,MBD3A,RRN3,MBD3,GATAD2B,MTA3,CHD4,MTA2,MBD3B |
Protein Function
UBTF has several biochemical functions, for example, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBTF itself. We selected most functions UBTF had, and list some proteins which have the same functions with UBTF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | TADA2B,GLI3,KIAA0101,KAT2B,LDB1,TP63,EZH1,DMRT1,ORC1L,REST |
Interacting Protein
UBTF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBTF here. Most of them are supplied by our site. Hope this information will be useful for your research of UBTF.
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References
- Delmani, FA; Torreblanca, J; et al. Biological activity and redistribution of nucleolar proteins of two different cell lines treated with cis-dichloro-1,2-propylenediamine-N,N,N ',N '-tetraacetato ruthenium (III) (RAP). INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY 52:579-588(2014).
- Yang, XY; Jin, Y; et al. Appearance of the pituitary factor Pit-1 increases chromatin remodeling at hypersensitive site III in the human GH locus. JOURNAL OF MOLECULAR ENDOCRINOLOGY 45:19-32(2010).
