UBR2

  • Official Full Name

    Ubiquitin protein ligase E3 component n-recognin 2

  • Overview

    Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).[supplied by OMIM]

  • Synonyms

    UBR2;Ubiquitin protein ligase E3 component n-recognin 2;Rabbit;Human;Rabbit Anti-Human UBR2 Polyclonal Antibody;Rabbit Anti-Human UBR2;Polyclonal Antibody;Rabbit Anti-Human UBR2 Antibody;Polyclonal;Rabbit Anti-Human UBR2 Polyclonal;Antibody;Rabbit Anti-Human Ubiquitin protein ligase E3 component n-recognin 2 Polyclonal;Rabbit Anti-Human Ubiquitin protein ligase E3 component n-recognin 2 Antibody;Anti-Human UBR2 Polyclonal;Anti-Human UBR2 Antibody;Anti-Human Ubiquitin protein ligase E3 component n-recognin 2 Polyclonal;Anti-Human Ubiquitin protein ligase E3 component n-recognin 2 Antibody;Anti-Human UBR2;Anti-UBR2;Anti-Human Ubiquitin protein ligase E3 component n-recognin 2;Anti-Ubiquitin protein ligase E3 component n-recognin 2
Cat.# Product name Source (Host) Species Tag Protein Length Price
UBR2-3561H Recombinant Human UBR2, GST-tagged E.coli Human GST 1-347aa
UBR2-1876HCL Recombinant Human UBR2 cell lysate Human Non

    Involved Pathway

    UBR2 involved in several pathways and played different roles in them. We selected most pathways UBR2 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class I MHC mediated antigen processing &amp RNF220,GAN,PJA2,CMTM2A,RNF182,RNF144B,TRIM69,TRAF7,RNF25,CD207
    Proteasome degradation ASB11,ASB4,TPP2,RNF220,ASB13,HUWE1,WSB1,KLHL20,DZIP3,TRIM41
    Adaptive Immune System KIF5B,AP2S1,RAP1GAP2,AKT3,LRRC41,TRIM41,MGC174857,CD200R3,FBXO3,FBXO44
    presentation DTX3L,RNF138,KLHL21,RBCK1,TRIM9,ASB14,RNF182,UBR1,ASB11,UBE2F
    Antigen processing: Ubiquitination &amp ASB14,KLHL20,TRIM41,BLMH,SH3RF1,RNF34,LTN1,ASB11,HECTD3,ASB10
    Immune System DYNC1I1,STUB1,LAT2,LRRFIP1,KIF2B,MX2,TRIM14,IFITM3,HUWE1,RNF41

    Protein Function

    UBR2 has several biochemical functions, for example, leucine binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBR2 itself. We selected most functions UBR2 had, and list some proteins which have the same functions with UBR2. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding KDM5A,MIB2,MMP1A,C11orf54,PRKCBB,TNKS,ACE,ZDHHC21,ZNF253,PRKCB
    ubiquitin protein ligase activity HACE1,TOPORS,MGRN1,UBE2KB,RNF152,RNF217,RNF34,MDM2,CDK8,UBE3A
    protein binding NUDT14,STK3,SHFM1,TEAD1,DCTN4,TPD52,STAT5A,PLEK,ERO1LB,MIPOL1
    ligase activity NEDD4L,MDM2,TRIM9,ADSSL,TRAF7,TTLL11,MIB2,ZSWIM2,RNF114,RNF115
    leucine binding UBR1,GLUD1,GLUD2

    Interacting Protein

    UBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBR2.

    vif;Ttll7;UBXN7;MYC;NES;TIRAP;Dynlrb1;UBXN1;Naa11;SGOL1;MRPL50;FAF2;Cdc26;PARD6B;FAF1

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