UBE4A

  • Official Full Name

    ubiquitination factor E4A

  • Overview

    This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohns disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

  • Synonyms

    UBE4A;ubiquitination factor E4A;ubiquitination factor E4A (homologous to yeast UFD2) , ubiquitination factor E4A (UFD2 homolog, yeast);ubiquitin conjugation factor E4 A;E4;KIAA0126;UBOX2;UFD2;ubiquitination factor E4A (UFD2 homolog, yeast);MGC13

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Rat
  • E.coli
  • Mammalian Cell
  • HEK293
  • HEK293T
  • His
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
UBE4A-3551H Recombinant Human UBE4A, His-tagged E.coli Human His C-350aa
UBE4A-17741M Recombinant Mouse UBE4A Protein Mammalian Cell Mouse His
UBE4A-2599C Recombinant Chicken UBE4A Mammalian Cell Chicken His
UBE4A-6406R Recombinant Rat UBE4A Protein Mammalian Cell Rat His
UBE4A-480H Recombinant Human UBE4A Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
UBE4A-6028H Recombinant Human UBE4A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
UBE4A-6062R Recombinant Rat UBE4A Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
UBE4A-6062R-B Recombinant Rat UBE4A Protein Pre-coupled Magnetic Beads HEK293 Rat
UBE4A-9844M Recombinant Mouse UBE4A Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
UBE4A-9844M-B Recombinant Mouse UBE4A Protein Pre-coupled Magnetic Beads HEK293 Mouse
Ube4a-997M Recombinant Mouse Ube4a Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    UBE4A involved in several pathways and played different roles in them. We selected most pathways UBE4A participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis UBE2QL1,ERCC8,CDC26,ANAPC4,TCEB1,CDC16,XIAP,UBE2I,UBE2E3,CUL1A

    Protein Function

    UBE4A has several biochemical functions, for example, GTPase inhibitor activity,Roundabout binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE4A itself. We selected most functions UBE4A had, and list some proteins which have the same functions with UBE4A. You can find most of the proteins on our site.

    Function Related Protein
    proteoglycan binding CECR1A,CECR1,CTSK,CTSB,SLIT2,FCN2,COL5A1,NID1,THBS1,CTSS
    protein homodimerization activity TARBP2,EEA1,ECE1,KCNK9,IZUMO1,IMPA2,CSF1,ERBB3,EFR3A,CLIC6
    laminin-1 binding SLIT2,NTN4,NID1,Shh,DAG1,LACRT
    Roundabout binding SLIT1,SLIT3,SLIT1B,SLIT2,GM4980,SLIT1A,TGFB1I1
    chemorepellent activity SLIT2,SEMA3G,APOA1,EPHA7,SEMA3C,SEMA5B,SEMA3AA,SEMA3D,SEMA3BL,SEMA3GB
    identical protein binding TRADD,MRFAP1L1,LDHA,PRDX1,GLUD1,GLUL,RUVBL2,PFKFB1,PON2,RABAC1
    protein binding GLE1,LIMD2,LRCH1,ADAMTS4,MS4A3,NOTCH4,KIAA1217,ADH1A,ELMO1,KRTAP4-11
    GTPase inhibitor activity TNK2,PDE6D,ARL2,IPO5,SLIT2,RHOH,GPS2,RTKN,GPS1,CDC42SE1
    heparan sulfate proteoglycan binding GPC3,GPC1,CFH,FST,AZU1,GPC1B,GPC6A,PLA2G2D,SLIT2,SEMA5A

    Interacting Protein

    UBE4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE4A here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE4A.

    MAVS;PTP4A3;UBE2D1;UBE2D3;UBE2D2;UBE2D4;CBX7

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