UBE2N
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Official Full Name
ubiquitin-conjugating enzyme E2N -
Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived;proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or;E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the;E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication;repair. -
Synonyms
UBE2N;ubiquitin-conjugating enzyme E2N;ubiquitin conjugating enzyme E2N (homologous to yeast UBC13) , ubiquitin conjugating enzyme E2N (UBC13 homolog, yeast);ubiquitin-conjugating enzyme E2 N;MGC8489;UBC13;UbcH ben;yeast UBC13 homolog;ubiquitin-p
Recombinant Proteins
- Human
- Cynomolgus
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Insect Cell
- E. coli
- GST
- His
- Non
- Myc&DDK
- His&Strep
- His&Fc&Avi
Involved Pathway
UBE2N involved in several pathways and played different roles in them. We selected most pathways UBE2N participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2N were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | SOCS1A,UBE2NA,NEDD4L,UBE2G1B,PRP19,BIRC2,CUL2,UBE2D1B,HERC3,KEAP1 |
Protein Function
UBE2N has several biochemical functions, for example, ATP binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2N itself. We selected most functions UBE2N had, and list some proteins which have the same functions with UBE2N. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | HSPA7,UBE2G1B,RFC2,ACSM1,CSF1R,ABCC5,NEK8,RLN1,MYO6B,RYK |
| protein binding | SDPR,UBL5,KRT80,AZGP1,H2-AA,SORBS2,GPAA1,NPHS1,CD59,RXRB |
| ubiquitin conjugating enzyme activity | UBE2T,UBE2S,UBE2J1,UBE2E2,UBE2O,UBE2V1,UBE2D4,UBE2A,UBE2Z,UBE2L3 |
| ubiquitin-protein transferase activity | PAX6,UBE2A,MDM2,TRIM37,RNF4,FEM1B,RNF144B,FBXO25,BARD1,FBXL14B |
| poly(A) RNA binding | LSM4,PPAN,SRSF7,CCDC9,LSM6,PSPC1,MRPL22,HIST1H4H,FAM46A,TRUB2 |
| ubiquitin protein ligase binding | FAF1,SUMO2,TNFRSF14,RNF34,DIO2,CUL3,RRAGA,CASP10,PDE4D,JKAMP |
| ubiquitin binding | SQSTM1,NUP62,NBR1,FAF2,DNAJC2,PER2,FAF1,RNF168,BCL10,C6orf106 |
| ubiquitin protein ligase activity | RNF126,UBR5,RNF25,RNF144A,UBE2KB,TRAF6,HERC3,RNF13,CCNB1IP1,RNF149 |
Interacting Protein
UBE2N has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2N here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2N.
UBE2V1;STUB1
Resources
Research Area
Ubiquitin-related Molecules in the Akt PathwayDNA Damage and Repair
E2 Ubiquitin/Ubl Conjugating Enzymes
Post-translational Modification of NFkB/IkB
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References
