UBE2L6
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Official Full Name
ubiquitin-conjugating enzyme E2L 6 -
Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
UBE2L6;ubiquitin-conjugating enzyme E2L 6;ubiquitin/ISG15-conjugating enzyme E2 L6;UBCH8;ubiquitin-protein ligase L6;ubiquitin carrier protein L6;retinoic acid induced gene B protein;retinoic acid-induced gene B protein;RIG-B;MGC40331
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- GST
- Non
- His
- His&Strep
- Myc&DDK
- His&Fc&Avi
Involved Pathway
UBE2L6 involved in several pathways and played different roles in them. We selected most pathways UBE2L6 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2L6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| presentation | TRIM50,UBE2F,SPSB4,RNF220,WSB1,ASB17,DTX3L,RNF138,ASB18,SPSB1 |
| Class I MHC mediated antigen processing & | BLMH,CTSL1,UBE2J2,WWP1,VPRBP,ASB4,RNF111,UBR2,RNF123,UBE2F |
| Cytokine Signaling in Immune system | FGF10B,CSF2RB,DUSP4,FGF18B,DUSP7,IRF2,CISH,SPTA1,JAK3,CRK |
| ISG15 antiviral mechanism | KPNA3,IFIT14,EIF4E3,IFIT11,KPNA4,EIF4G2A,KPNA5,EIF4G2,IFIT12,IFIT10 |
| Proteasome degradation | UBR2,RNF182,TRIM9,RNF123,STUB1,UBR1,RNF220,ASB6,TRIM50,MKRN1 |
| DNA Repair | PPP4R2B,POLI,TDP1,DNA2,RNF111,MCRS1,RHNO1,FAM175A,MAD2L2,SMARCA5 |
| Adaptive Immune System | UBE2J2,SPSB2,SEC61B,AF251705,KIF20A,MICA,CD200R4,RNF34,LAIR1,UBA5 |
| DNA Damage Bypass | MAD2L2,RAD18,POLD3,USP10,SPRTN,KIAA0101,USP43A,DTL,DDB1,USP43 |
| Antiviral mechanism by IFN-stimulated genes | IFIT14,IFIT12,EIF4G2A,DPF1,IFIT11,EIF4E3,IFIT10,NUPL2,EIF4A1,HERC5 |
Protein Function
UBE2L6 has several biochemical functions, for example, ISG15 transferase activity,protein binding,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2L6 itself. We selected most functions UBE2L6 had, and list some proteins which have the same functions with UBE2L6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ISG15 transferase activity | UBE2E1,HERC5,UBE2E2 |
| ubiquitin-protein transferase activity | CBL,TRIM36,UHRF1,TRAF2,RNF43,RNF13,PRKCQ,TRIM68,RNF139,UBE2D2 |
| protein binding | TPSAB1,KCTD13,ELF4,LATS1,USF1,IL2RG,EHD1,MIEF1,MYBL2,KRT25 |
Interacting Protein
UBE2L6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2L6 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2L6.
ARIH2;RNF144B;LONRF1;RBCK1;RNF19B
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