TPM4

  • Official Full Name

    tropomyosin 4

  • Overview

    This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    TPM4;tropomyosin 4;tropomyosin alpha-4 chain;TM30p1;tropomyosin-4

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Mammalian Cells
  • Human Cells
  • HEK293
  • GST
  • His
  • Non
  • DDK&Myc
  • Avi&Fc&His

    Involved Pathway

    TPM4 involved in several pathways and played different roles in them. We selected most pathways TPM4 participated on our site, such as Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes,Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with TPM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hypertrophic cardiomyopathy (HCM) TNF,ITGA8,IL6,ACE,TNNI3,MYL2,CACNG1,CACNB2,CACNB4,CACNG6
    Cardiac muscle contraction ATP1B2A,UQCR11,ATP1B1B,TNNC1B,ATP1B3B,COX8C,COX7A2,COX5B,TPM4B,CACNA1SB
    Dilated cardiomyopathy ITGB3,PRKACA,ACTG1,EMD,CACNG6,CACNG8,CACNB3,MYL3,ATP2A2,TNNC1
    Adrenergic signaling in cardiomyocytes GNAI3,SCN5A,CACNG3,NETO2,CAMK2D2,TPM1,MYH7,ATP1B1,PPP2R5EA,PRKACAA

    Protein Function

    TPM4 has several biochemical functions, for example, actin binding,calcium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPM4 itself. We selected most functions TPM4 had, and list some proteins which have the same functions with TPM4. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding PCDH18,HMCN1,GUCA1E,PCDHAC2,VCANB,PVALB1,PCDH2G5,CABP1A,DSG1C,CLSTN3
    protein binding PPARD,GAPDHS,ZNF614,PARN,AUNIP,SYTL1,DCTPP1,LINC01588,TBKBP1,PIP4K2B
    structural constituent of muscle PLEC,MYL1,PDLIM3,MYL3,MYOM1,JPH1,TCAP,MYL2,ASPH,ACTN2
    actin binding HIP1,TNS4,CAPG,BAIAP2L1,SLC4A1,PARVAA,GCET2,BCL7B,NRAP,SYNE1

    Interacting Protein

    TPM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPM4.

    q99ib8-pro_0000045599;PACSIN1;Mast3;ssrna_ac;SLC33A1;Flot1;ATF2;FLNA;CDK2;AKT1;MYH9;ADD1;PPP1CC;IQGAP1;CAPZA2;ARRB1;Tpm1

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