TAP1
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Official Full Name
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) -
Overview
CRTAP is found in articular chondrocytes and is expressed in a variety of other tissues. Defects in CRTAP are the cause of osteogenesis imperfecta type 7 (OI-7). OI is a connective tissue disorder characterized by bone fragility and low bone mass. OI-7 is an autosomal recessive form of OI. -
Synonyms
TAP1;transporter 1, ATP-binding cassette, sub-family B (MDR/TAP);APT1;PSF1;ABC17;ABCB2;RING4;TAP1N;D6S114E;FLJ26666;FLJ41500;TAP1*0102N;ABC 17;ATP binding cassette sub family B (MDR/TAP) member 2;ATP binding cassette transporter;Peptide transporter PSF 1;Transporter 1 ATP binding cassette sub family B (MDR/TAP);Peptide supply factor 1;Really interesting new gene 4 protein2;PSF-1;antigen peptide transporter 1;ABC transporter, MHC 1;transporter, ATP-binding cassette, major histocompatibility complex, 1Y3;transporter associated with antigen processing
Recombinant Proteins
- Human
- Rat
- Chicken
- E.coli
- E.Coli/Yeast
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- T7
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TAP1-3113H | Recombinant Human TAP1, GST-tagged | E.coli | Human | GST | C-term-300aa | |
| Tap1-3511R | Recombinant Rat Tap1, His-tagged | E.Coli/Yeast | Rat | His | 725 |
|
| TAP1-3512H | Recombinant Human TAP1, His-tagged | E.Coli/Yeast | Human | His | 808 |
|
| TAP1-3878C | Recombinant Chicken TAP1 | Mammalian Cells | Chicken | His |
|
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| TAP1-7882H | Recombinant Human TAP1 protein, His & T7-tagged | E.coli | Human | His&T7 | Tyr525~Glu808 |
|
| TAP1-1254HCL | Recombinant Human TAP1 293 Cell Lysate | HEK293 | Human | Non |
|
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| TAP1-6397H | Recombinant Human TAP1 Protein (Tyr525-Glu808), N-His tagged | E.coli | Human | His | Tyr525-Glu808 |
|
| TAP1-675H | Recombinant Human TAP1 Protein, GST-tagged | Wheat Germ | Human | GST | 1-808 aa |
|
| TAP1-6821HF | Recombinant Full Length Human TAP1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 808 amino acids |
|
Involved Pathway
TAP1 involved in several pathways and played different roles in them. We selected most pathways TAP1 participated on our site, such as ABC transporters,Phagosome,Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | MARCO,ATP6V0CB,NOS1,ATP6V1AA,CD209,M6PR,ATP6V0A1B,ITGA2,CALR,TFR1A |
| nodeficiency | IL2RG,CD4,CD8B1,RFXAP,CD8A,IL7R,RFX5,CD8B,CD3D,CD3E |
| Primary i | RFXANK,RFX5, Cd79b,UNG,BTK,BLNK,TAP2,AICDA,PTPRC,RFXAP |
| Antigen processing and presentation | KLRC3,KIR2DL3,KIR3DL1,CD8A,HLA-DQB1,CTSS,HSPA4,HLA-DMB,KIR2DL4,CD4 |
| ABC transporters | ABCC11,ABCA5,ABCA3,ABCB8,ABCC6,ABCC4,ABCC1,ABCC12,ABCC9,ABCG8 |
| Herpes simplex infection | C1QBP,IFN-a,SRSF3,HCFC1B,PER2,C3,HLA-DPA1,SRSF2B,C3A.3,PPP1CBL |
Protein Function
TAP1 has several biochemical functions, for example, ADP binding,ATP binding,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by TAP1 itself. We selected most functions TAP1 had, and list some proteins which have the same functions with TAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase activity, coupled to transmembrane movement of substances | ABCA13,ABCC1,ABCG2A,ABCC6,ABCG2D,ABCA4A,ABCD3B,ABCA5,DPY19L2,ABCB6A |
| tapasin binding | TAP2 |
| contributes_to peptide transporter activity | TAP2 |
| ATP binding | ATP2A2A,HSP104,Abcb1b,TNK2,BAZ1B,CDK2,PDXK,DYNC1LI2,SLC22A5,ABL2 |
| peptide transporter activity | DISP1 |
| TAP1 binding | TAP2,TAPBP,HLA-F |
| MHC class I protein binding | CD244,ATP5B,HLA-E,TUBB,CD8B,LILRB2,TAPBP,TUBB4B,BCAP31,VCP |
| TAP2 binding | HLA-F,TAPBP |
| peptide-transporting ATPase activity | ABCB9 |
Interacting Protein
TAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAP1.
TAP2;TAPBP
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References
- Tuncel, J; Haag, S; et al. Natural Polymorphisms in Tap2 Influence Negative Selection and CD4 : CD8 Lineage Commitment in the Rat. PLOS GENETICS 10:-(2014).
- Gameiro, SR; Jammeh, ML; et al. Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing. ONCOTARGET 5:403-416(2014).
