Sfrp4
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Official Full Name
secreted frizzled-related protein 4 -
Overview
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008] -
Synonyms
SFRP4;secreted frizzled-related protein 4;FRP-4;FRPHE;sFRP-4;frizzled protein, human endometrium
Recombinant Proteins
- Human
- Rat
- Rhesus macaque
- Mouse
- E.coli
- HEK293
- CHO
- Wheat Germ
- Mammalian Cell
- Human Cell
- His
- Non
- His&Fc&Avi
Involved Pathway
Sfrp4 involved in several pathways and played different roles in them. We selected most pathways Sfrp4 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Sfrp4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | AXIN2,CAMK2D1,NLK2,RAC2,WNT2,FZD1,WNT7AA,PPP3CCA,RAC1A,TCF7L1A |
Protein Function
Sfrp4 has several biochemical functions, for example, NOT G-protein coupled receptor activity,NOT Wnt-activated receptor activity,Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Sfrp4 itself. We selected most functions Sfrp4 had, and list some proteins which have the same functions with Sfrp4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT G-protein coupled receptor activity | SFRP1,SFRP2,SFRP1B,SFRP1A,LGR6,LGR5,SZL,LGR4,FRZB |
| Wnt-protein binding | FZD9B,PTPRO,FZD6,GPR177,WLS,SZL,FZD3A,LRP5,SFRP1B,GM12824 |
| NOT Wnt-activated receptor activity | SZL,SFRP2,SMO,SETD6,SFRP1B,SFRP1A,FRZB,SFRP1,TSPAN12 |
| protein binding | PHF20L1,PRKG1,GTF2F1,SNX9,TRIM63,TIPRL,COG1,APOBEC3G,TAF9B,ESR1 |
Interacting Protein
Sfrp4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Sfrp4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Sfrp4.
AURKA;BUB1;NRAS;ERBB2;PFKM;CKMT1B;MCC;p27958-pro_0000037576;CTNNA1;BMPR1A;PIK3CA;PMS2;PTPN12;PTPRJ;SMAD4;PDGFRL;ychF;CDKN2A;AP2M1;DLC1
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References
- Miao, CG; Huang, C; et al. MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats. CELLULAR SIGNALLING 25:598-608(2013).
- Liu, YA; Kodithuwakku, SP; et al. Excessive ovarian stimulation up-regulates the Wnt-signaling molecule DKK1 in human endometrium and may affect implantation: an in vitro co-culture study. HUMAN REPRODUCTION 25:479-490(2010).
